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Immunity induced by yellow fever vaccination in the elderly (60yrs or older)traveller


- candidate number2709
- NTR NumberNTR1040
- ISRCTNISRCTN42180653
- Date ISRCTN created5-sep-2007
- date ISRCTN requested31-aug-2007
- Date Registered NTR23-aug-2007
- Secondary IDsLUMC 
- Public TitleImmunity induced by yellow fever vaccination in the elderly (60yrs or older)traveller
- Scientific TitleImmunity induced by yellow fever vaccination in the elderly (60yrs or older)traveller
- ACRONYMYFOLD
- hypothesisThe induction of immunity might be slower in older persons than in younger individuals. This could influence the occurence of adverse events induced by the vaccine.
- Healt Condition(s) or Problem(s) studiedYellow Fever, Older adults, Neutralizing antibodies, Adverse events, Travellers
- Inclusion criteriaElderly group: 1. Age of 60yrs or older; 2. Indication for yellow fever vaccination according to Dutch travel guidelines Control group: age under 60yrs
- Exclusion criteria1. Immune suppression due to disease or medication; 2. Pregnancy
- mec approval receivedno
- multicenter trialyes
- randomisedyes
- masking/blindingNone
- controlActive
- groupParallel
- Type-
- Studytypeintervention
- planned startdate 1-okt-2007
- planned closingdate1-okt-2008
- Target number of participants60
- InterventionsYellow fever vaccination (only an extra intervention in control group), blood drawing and urine sampling
- Primary outcome1. Neutralizing antibodies; 2. Yellow fever viremia
- Secondary outcome1. Presence of yellow fever virus proteins in urine samples, 2. adverse events
- Timepoints
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIESMD. A.H.E. Roukens
- CONTACT for SCIENTIFIC QUERIESMD. A.H.E. Roukens
- Sponsor/Initiator Leiden University Medical Center (LUMC), Department of Infectious Diseases
- Funding
(Source(s) of Monetary or Material Support)
Leiden University Medical Center (LUMC), Department of Infectious Diseases
- Publications
- Brief summaryComparison of neutralizing antibodies and viremia induced by yellow fever vaccination between elderly travellers en younger controls. Adverse events following yellow fever vaccination will be monitored.
- Main changes (audit trail)
- RECORD23-aug-2007 - 24-sep-2007


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