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A crossover intervention trial to evaluate the impact of rapid on-admission screening in preventing MRSA infection in surgery.


- candidate number2710
- NTR NumberNTR1041
- ISRCTNISRCTN06603006
- Date ISRCTN created5-sep-2007
- date ISRCTN requested31-aug-2007
- Date Registered NTR27-aug-2007
- Secondary IDs 
- Public TitleA crossover intervention trial to evaluate the impact of rapid on-admission screening in preventing MRSA infection in surgery.
- Scientific TitleA crossover intervention trial to evaluate the impact of rapid on-admission screening in preventing MRSA infection in surgery.
- ACRONYMNONE
- hypothesisTo determine the effect of an early MRSA detection strategy on nosocomial MRSA infections in a cohort of surgical patients at a large teaching hospital.
- Healt Condition(s) or Problem(s) studiedMethicillin-resistant Staphylococcus aureus (MRSA)
- Inclusion criteriaAll patients admitted to the surgical department for >24 hours.
- Exclusion criteriaAmbulatory surgery.
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupCrossover
- TypeSingle arm
- Studytypeintervention
- planned startdate 1-jul-2004
- planned closingdate30-sep-2006
- Target number of participants20000
- InterventionsRapid MRSA screening.
- Primary outcomeNumber of patients with nosocomial MRSA infection acquired in surgery, expressed as incidence per 1000 patient-days
- Secondary outcome1. Nosocomial MRSA acquisition rate (expressed as the rate of new MRSA cases detected by any type of clinical isolate in previously MRSA-free patients per 1000 patient-days);
2. The rate of surgical site infections (per 100 procedures) and other site-specific infections caused by MRSA.
- TimepointsN/A
- Trial web siteN/A
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIESMD, MS Stephan Harbarth
- CONTACT for SCIENTIFIC QUERIESMD, MS Stephan Harbarth
- Sponsor/Initiator SPCI / HUG
- Funding
(Source(s) of Monetary or Material Support)
The Geneva University Hospitals, Swiss National Science Foundation
- PublicationsIn preparation.
- Brief summaryBackground:
Carriage of methicillin-resistant Staphylococcus aureus (MRSA) places patients at risk for MRSA infection. Experts and politicians have repeatedly called for widespread admission screening to reduce nosocomial MRSA infection.

Objectives:
To determine the effect of an early MRSA detection strategy on nosocomial MRSA infections in a cohort of 21754 surgical patients at a large teaching hospital.

Methods:
We carried out a prospective, interventional cohort study using a cross-over design to compare two different MRSA control strategies (rapid screening plus standard control versus standard control only). Twelve surgical wards were assigned to 2 study groups and enrolled according to a pre-specified agenda, encompassing 4 study phases. Patients admitted for >24 h were screened upon admission by quick, multiplex PCR. MRSA infections acquired in surgery were the primary outcome measure.
- Main changes (audit trail)
- RECORD27-aug-2007 - 2-sep-2009


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