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Automatic Weaning Using Adaptive Support Ventilation (ASV) – Effect of an Early Weaning Protocol on Time till Extubation of Post–Coronary Artery Bypass Surgery Patients.


- candidate number2900
- NTR NumberNTR1136
- ISRCTNISRCTN wordt niet meer aangevraagd
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR20-nov-2007
- Secondary IDsincomplete 
- Public TitleAutomatic Weaning Using Adaptive Support Ventilation (ASV) – Effect of an Early Weaning Protocol on Time till Extubation of Post–Coronary Artery Bypass Surgery Patients.
- Scientific TitleAutomatic Weaning Using Adaptive Support Ventilation (ASV) – Effect of an Early Weaning Protocol on Time till Extubation of Post–Coronary Artery Bypass Surgery Patients.
- ACRONYMN/A
- hypothesisWe hypothesize time till extubation of post–CABG patients can be shortened by using an early weaning protocol with ASV.
- Healt Condition(s) or Problem(s) studiedMechanical ventilation
- Inclusion criteria1. Planned and uneventful CABG;
2. Following receipt of verbal and written information about the trial, the patient must provide signed and dated informed consent before any trial related activity is carried out.
- Exclusion criteria1. History of any pulmonary disease;
2. History of any previous pulmonary surgery;
3. Valve surgery;
4. Arrival at the ICU with intra–aortic balloon pump, or inotropes at a more then usual rate (maximum dosages in ml per hour: dopamine [4], norepinephrine [4], dobutamin [4] or epinephrine [any rate]).
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 22-nov-2007
- planned closingdate22-nov-2008
- Target number of participants128
- InterventionsPatients will be weaned from the ventilator using a standard protocol and an early weaning protocol.
- Primary outcome1. Duration of ventilation.
- Secondary outcome1. Length of stay in the ICU;
2. Number of failed extubations;
3. Number of ABG–analysis.
- TimepointsN/A
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESProf. Dr. M.J. Schultz
- CONTACT for SCIENTIFIC QUERIESProf. Dr. M.J. Schultz
- Sponsor/Initiator Academic Medical Center (AMC), Department of Intensive Care
- Funding
(Source(s) of Monetary or Material Support)
- PublicationsN/A
- Brief summaryAdaptive support ventilation (ASV) is a microprocessor–controlled mode of mechanical ventilation that maintains an operator preset minimum minute ventilation, independent of activity of the patient. ASV provides automatic selection of ventilatory settings and continuous – breath by breath – adaptation. In addition, it’s closed–loop control switches automatically from pressure controlled (PC) mechanical ventilation to pressure support (PS) mechanical ventilation, according to the patient status.
Previous studies have tested the efficiency, safety, and adaptability of ASV. A weaning protocol based on ASV simplifies ventilatory management; in addition, ASV shortens duration of tracheal intubation after fast–track cardiothoracic surgery. We recently studied ASV in post–coronary artery bypass surgery (CABG) patients in our setting and found a reduction of the number of ventilatory–alarms and ventilator–manipulations [ISRCTN31808827; yet unpublished data]. However, weaning with ASV was not faster as compared to standard weaning. Indeed, mean duration of intubation and mechanical ventilation (i.e., time till extubation) was 17 hours – this is very much opposite to other studies on this subject, in which mean duration of time till extubation is ~ 10 hours3;4.
Aim of the study
We hypothesize time till extubation of post–CABG patients can be shortened by using an early weaning protocol with ASV.
- Main changes (audit trail)
- RECORD20-nov-2007 - 3-apr-2008


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