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Perioperative analgesia and postoperative pain processing


- candidate number3070
- NTR NumberNTR1259
- ISRCTNISRCTN wordt niet meer aangevraagd
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR1-mrt-2008
- Secondary IDs2004/064 MEC
- Public TitlePerioperative analgesia and postoperative pain processing
- Scientific TitleEffects of extended multimodal analgesia on early postoperative pain processing: A pilot study
- ACRONYMPAPPP
- hypothesisExtended multimodal perioperative analgesia results in less hyperalgesia in the first postoperative week than standard perioperative analgesia
- Healt Condition(s) or Problem(s) studiedPost-operative pain, Analgesia, Hyperalgesia
- Inclusion criteria1. Patients for elective abdominal surgery with indication for combined epidural and general anaesthesia
- Exclusion criteria1. Previous abdominal or thoracic surgery
2. Chronic pain syndrome
3. Chronic analgesic medication
4. Contraindication to epidural anaesthesia
5. Contraindications to S-ketamine or diclofenac
6. Major psychiatric disease
7. Inability to comprehend or participate in quantitative sensory testin
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-jun-2004
- planned closingdate1-feb-2007
- Target number of participants24
- InterventionsVerum: 48h continuous epidural analgesia at 5 ml/h of bupivacaine 0.25% with fentanyl 2 mcg/ml, 48h continuous S-ketamine infusion at 0.5 mcg/kg/min, 1 week diclofenac suppositories at 3x50mg
Control: dummy epidural analgesia, placebo infusion, placebo suppositories
- Primary outcomeIncidence of electrical and mechanical hyperalgesia on postoperative days 1 and 5
- Secondary outcomePain scores at rest and on movement, cold pressor test results, presence of chronic pain 6 months postoperatively
- Timepoints- preoperative
- 1 day postoperative
- 5 days postoperative
- 6 months postoperative
- Trial web siteN/A
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIESDr. Oliver H.G. Wilder-Smith
- CONTACT for SCIENTIFIC QUERIESDr. Oliver H.G. Wilder-Smith
- Sponsor/Initiator Radboud University Nijmegen Medical Centre, Department of Anaesthesiology
- Funding
(Source(s) of Monetary or Material Support)
ZON-MW, The Netherlands Organization for Health Research and Development, Radboud University Nijmegen Medical Centre, Department of Anaesthesiology
- PublicationsN/A
- Brief summaryThis study investigates the effects of intensive perioperative analgesia and preoperative pain processing on postoperative pain and pain processing
- Main changes (audit trail)
- RECORD14-feb-2008 - 7-apr-2008


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