search  
 


Home

Who are we?

Why
register?


Signup for
registration


Online registration

Log in to register
your trial


Search a trial

NRT en CCMO

Contact

NEDERLANDS





MetaRegister
van CCT (UK)


ISRCTN-Register
van CCT (UK)


Transcranial magnetic stimulation to the right parietal cortex in the treatment of depression.


- candidate number3209
- NTR NumberNTR1279
- ISRCTNISRCTN wordt niet meer aangevraagd
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR17-apr-2008
- Secondary IDsTMSDEP18061975 
- Public TitleTranscranial magnetic stimulation to the right parietal cortex in the treatment of depression.
- Scientific TitleTherapeutic effects of 2 Hz repetitive transcranial magnetic stimulation to the right parietal cortex in depression.
- ACRONYMTMS
- hypothesisTen consecutive sessions of 2 Hz TMS (inter-pulse interval: 1 sec) at 90% MT to the right parietal cortex (2400 pulses p/session) will have antidepressant effects.
- Healt Condition(s) or Problem(s) studiedDepression, Transcranial magnetic stimulation (TMS)
- Inclusion criteria1. Primary diagnosis of depressive disorder according to the DSM-IV (APA 2000);
2. => 15 score on the Hamilton Rating Scale for Depression (HAM-D).
- Exclusion criteria1. History of seizures;
2. Neurological conditions;
3. Metal objects in or around the body that cannot be removed (i.e., cochlear implant, surgical clips, piercing, cardiac pacemaker);
4. Heart disease;
5. Pregnancy;
6. Drug and alcohol abuse.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlPlacebo
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-jul-2004
- planned closingdate31-dec-2007
- Target number of participants34
- InterventionsTranscranial magnetic stimulation: 2 Hz TMS (inter-pulse interval: 1 sec) at 90% MT to the right parietal cortex (2400 pulses p/session). 10 sessions in total.
- Primary outcomeThe percentage change from baseline on the HAM-D scores
- Secondary outcomeN/A
- Timepointst=1: week 0 - baseline;
t=2: week 2 - endpoint.
- Trial web siteN/A
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIESMD PhD G.F. Koerselman
- CONTACT for SCIENTIFIC QUERIESMD PhD G.F. Koerselman
- Sponsor/Initiator St. Lucas Andreas Hospital, Department of Psychiatry
- Funding
(Source(s) of Monetary or Material Support)
Netherlands Organization for Scientific Research (NWO)
- PublicationsIn preparation
- Brief summaryBackground:
The aim of the current treatment study was to evaluate the therapeutic effects of transcranial magnetic stimulation (TMS) over the right parietal cortex in depression.

Methods:
In a double-blind sham-controlled design ten consecutive sessions of 2 Hz TMS (inter-pulse interval: 1 sec) at 90% MT to the right parietal cortex (2400 pulses p/session) were applied to thirty-four patients with the primary diagnosis of DSM-IV depression and a > 15 score on the 17-item Hamilton Rating Scale for Depression (HAM-D). The primary outcome measures were the percentage change from baseline on the 17-item HAM-D scores after ten sessions, and the percentage clinical (> 50% reduction in HAM-D score) and partial clinical responders (> 30% reduction in HAM-D score).

Results:
The reduction of HAM-D scores in the real TMS treatment (meanreal SD, -19.9 32.5%) was not statistically different from the sham TMS treatment (meansham SD, -5.6 28.4%), and the number of clinical responders did not differ between treatments. However, a significant greater number of partial clinical responders was observed in the real (43.8%) as compared to the sham TMS treatment (6.3%).

Conclusions:
The current study provides the first evidence showing that 2 Hz TMS over the right parietal cortex may have antidepressant properties and warrants further research.
- Main changes (audit trail)
- RECORD17-apr-2008 - 18-jan-2010


  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar nederlands@trialregister.nl