search  
 


Home

Who are we?

Why
register?


Signup for
registration


Online registration

Log in to register
your trial


Search a trial

NRT en CCMO

Contact

NEDERLANDS





MetaRegister
van CCT (UK)


ISRCTN-Register
van CCT (UK)


Stress and psychosis.


- candidate number3214
- NTR NumberNTR1284
- ISRCTNISRCTN wordt niet meer aangevraagd
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR18-apr-2008
- Secondary IDs22382 CCMO
- Public TitleStress and psychosis.
- Scientific TitlePsychotic reactivity to stress: linking phenomenology, biology and genetics.
- ACRONYMSTRIP
- hypothesis- The level of psychotic reactivity differs between psychotic trait, state, and illness groups
- Psychotic reactivity is mediated by biological reactivity in terms of dopamine and cortisol reactivity
- The level of psychotic reactivity is influenced by genetic polymorphisms and early trauma
- Healt Condition(s) or Problem(s) studiedSchizophrenia, Psychosis, Stress
- Inclusion criteriaAll subjects:
1. Aged between 18-50
2. Sufficient command of the Dutch language
3. No intellectual impairment (IQ>80)

For patients:
1. Diagnosis of non-affective psychotic disorder
- Exclusion criteriaAll subjects:
1. Current use of psychotropic medication
2. Current cannabis dependence
3. Current alcohol dependence
4. Pregnancy
5. Severe endocrine, cardiovascular or brain disease
6. Having metal elements inside the body MRI)

For relatives:
1. A life-time history of psychotic disorder
For controls:
1. A life-time history or family history of psychotic disorders
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- Type2 or more arms, non-randomized
- Studytypeobservational
- planned startdate 1-jun-2008
- planned closingdate1-jun-2011
- Target number of participants165
- InterventionsThis is not an intervention study.
The study is about the effect of stress on the brain.
There is a control condition and a stress condition.
- Primary outcome* psychotic reaction
* change in D2 receptor binding
* cortisol reactivity
- Secondary outcome
- Timepoints* momentary assessment (60 measurement points - 10 times a day during 6 days)
* laboratory stress task
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES Inez Myin-Germeys
- CONTACT for SCIENTIFIC QUERIES Inez Myin-Germeys
- Sponsor/Initiator University Maastricht (UM)
- Funding
(Source(s) of Monetary or Material Support)
NARSAD, NWO (VIDI grant)
- PublicationsN/A
- Brief summaryThe essence of psychosis is that some individuals abnormally react to stress with psychotic symptoms. This will hereafter be referred to as psychotic reactivity to stress. Psychotic reactivity to stress is thought to be the result of an interaction between genetic and environmental predispositions on the one hand, and the impact of changes in the environment experienced as stressful on the other. However, the origins and mechanisms of psychotic reactivity to stress are still poorly understood, and this project contributes to their elucidation.
- Main changes (audit trail)
- RECORD18-apr-2008 - 1-apr-2009


  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar nederlands@trialregister.nl