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Epigenetic effects of IVF in placental tissue


- candidate number3240
- NTR NumberNTR1298
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR25-apr-2008
- Secondary IDs07-2-111 METC Maastricht
- Public TitleEpigenetic effects of IVF in placental tissue
- Scientific TitleEpigenetic effects of IVF in placental tissue: a pilot study
- ACRONYMN/A
- hypothesisThere are differences in epigenetic parameters between placental tissues from spontaneous pregnancies and from IVF pregnancies.
- Healt Condition(s) or Problem(s) studiedIn vitro fertilization (IVF), Placenta
- Inclusion criteria1. Patients pregnant after IVF or ICSI
2. Control group: spontaneous pregnant patients
- Exclusion criteria1. Twin gestations
2. Delivery before 37 weeks of gestation
3. Pregnancies after fertility treatment other than IVF or ICSI
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeintervention
- planned startdate 1-mei-2008
- planned closingdate1-mei-2009
- Target number of participants200
- InterventionsNone. In both groups, placental tissue will be collected after birth and examined for several epigenetic markers
- Primary outcomeThe expression levels of several imprinted genes in placental tissue from spontaneous and IVF pregnancies
- Secondary outcomeThe DNA methylation level of several imprinted genes in placental tissue from spontaneous and IVF pregnancies
- TimepointsPlacental tissue is collected after birth
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESDrs. E. Nelissen
- CONTACT for SCIENTIFIC QUERIESDr. J. Dumoulin
- Sponsor/Initiator University Hospital Maastricht (AZM)
- Funding
(Source(s) of Monetary or Material Support)
University Hospital Maastricht (AZM)
- PublicationsN/A
- Brief summaryIn animal models it has been demonstrated that assisted reproductive technologies (ART), such as ovarian stimulation and in vitro culture of embryos, can lead to abnormal epigenetic regulation of certain genes that are important during early development resulting in grossly abnormal foetal growth. Also in the human, own observations as well as those in published reports seem to indicate epigenetic deregulation after IVF and/or ICSI, albeit that the effects are less dramatic as in animal models. As the placenta has been shown as one of the tissues in which epigenetic deregulation leads to clearly aberrant methylation patterns and expression of imprinted genes, we hypothesize that differences in these epigenetic parameters will exist between placental tissues from spontaneous pregnancies and those resulting from IVF pregnancies.
- Main changes (audit trail)
- RECORD25-apr-2008 - 17-mei-2008


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