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Effect of dietary proteins on blood pressure


- candidate number3543
- NTR NumberNTR1362
- ISRCTNISRCTN wordt niet meer aangevraagd
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR30-jun-2008
- Secondary IDs08-3-041 MEC
- Public TitleEffect of dietary proteins on blood pressure
- Scientific TitleEffect of dietary proteins on blood pressure
- ACRONYMProPres
- hypothesisLowering of daily carbohydrate intake by 10% of total energy intake and isocaloric replacement by protein intake during 4 weeks will significantly reduce office and ambulatory blood pressure in overweight subjects with prehypertension or grade 1 hypertension.
- Healt Condition(s) or Problem(s) studiedOverweight, Obesity, Hypertension, Carbohydrates, Dietary proteins
- Inclusion criteria1. Men and women
2. BMI 25-30 kg/m2
3. High normal or untreated grade 1 hypertension (systolic blood pressure 130-159 mmHg, diastolic blood pressure 85-99 mmHg)
4. Age 20-65 years
- Exclusion criteria1. Smokers
2. Food allergies
3. Unwillingness to stop use of dietary supplements (except those provided in the study)
4. Use of prescription medication
5. Recent history of or current dieting
6. Gastrointestinal problems
7. Plasma creatinine < 60 mmol/L
8. Presence of urinary protein (stick test)
9. Fasting glucose > 7 mmol/L
10. At randomisation: average blood pressure of visits 1 and 2 outside inclusion range for blood pressure
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-sep-2008
- planned closingdate1-sep-2009
- Target number of participants150
- InterventionsCarbohydrate (maltodextrine) supplementation vs protein (mixture of dietary proteins) supplementation, 10% of total energy intake, isocaloric
- Primary outcomeChange in office and 24-h ambulatory blood pressure after 4 weeks intervention
- Secondary outcomeAcute postprandial effects on cardiac output, renal blood flow, forearm blood flow, endothelial function, sympathetic nervous system activity, renal function, ACE activity
Change in acute postprandial effects on cardiac output, renal blood flow, forearm blood flow, endothelial function, sympathetic nervous system activity, renal function, ACE activity after 4 weeks intervention
- TimepointsBaseline, 4 weeks intervention
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIESProf. Dr. M.A. Baak, van
- CONTACT for SCIENTIFIC QUERIESProf. Dr. M.A. Baak, van
- Sponsor/Initiator University Maastricht (UM), NUTRIM
- Funding
(Source(s) of Monetary or Material Support)
Top Institute Food & Nutrition
- PublicationsN/A
- Brief summaryThis trial will investigate the blood pressure lowering effect of dietary proteins and explore its underlying mechanism of action.
- Main changes (audit trail)
- RECORD30-jun-2008 - 22-aug-2008


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