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NGAL an early biomarker for acute kidney injury


- candidate number3828
- NTR NumberNTR1405
- ISRCTNISRCTN wordt niet meer aangevraagd
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR13-aug-2008
- Secondary IDsMEC2007-135 
- Public TitleNGAL an early biomarker for acute kidney injury
- Scientific TitleNeutrophil Gelatinase Associated Lipocalin an early biomarker for acute kidney injury.
- ACRONYMNGAL study
- hypothesisNGAL is an early predictive biomarker for acute kidney injury in a heterogeneous adult ICU population.
- Healt Condition(s) or Problem(s) studiedBiomarkers, Acute kidney injury, Neutrophil Gelatinase Associated Lipocalin (NGAL)
- Inclusion criteriaAll consequetively admitted patients on a general adult ICU
- Exclusion criteria1. Age under 18
2. Nefrectomy
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupParallel
- Type[default]
- Studytypeintervention
- planned startdate 1-sep-2007
- planned closingdate1-apr-2008
- Target number of participants700
- InterventionsThis observational study was conducted in order to determine the ability of NGAL -an early biomarker of tubular damage- to predict the presence and development of Acute Kidney Injury (AKI) in a general adult ICU population. Plasma and urine NGAL were measured using the conventional ELISA for plasma and urine and a rapid bed side immunoassay for plasma. During the study period all consecutively admitted patients were included.
- Primary outcomeObservational study
- Secondary outcomeObservational study
- TimepointsThere were eight timepoints for NGAL plasma and urine measurements: T=0, 4, 8, 24, 36, 48, 60 and 72 hours after admission to the ICU.
- Trial web sitehttp://www.ngal.nl
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIESMD. Hilde Geus, de
- CONTACT for SCIENTIFIC QUERIESMD. Hilde Geus, de
- Sponsor/Initiator Erasmus Medical Center
- Funding
(Source(s) of Monetary or Material Support)
Biosite Incorporated
- PublicationsN/A
- Brief summaryThis prospective observational single centre study was conducted to determine the relationship between NGAL in plasma and urine and the development of AKI in a heterogeneous adult ICU population in which the timing of renal damage is not well defined. The predictive ability of NGAL is determined and it's earlier detection properties compared to functional parameters like serum Creatinine and Cystatin C. Two methods of NGAL detection will be used and their test properties compared.
- Main changes (audit trail)
- RECORD13-aug-2008 - 22-aug-2008


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