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van CCT (UK)


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van CCT (UK)


Molecular analysis of cancers in the large intestine in patients that use statins.


- candidate number3852
- NTR NumberNTR1417
- ISRCTNISRCTN wordt niet meer aangevraagd
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR20-aug-2008
- Secondary IDs2008-2 
- Public TitleMolecular analysis of cancers in the large intestine in patients that use statins.
- Scientific TitleMolecular analysis of colorectal cancers in patients receiving statin therapy
- ACRONYMMACCS
- hypothesisThe action of statins in CRC is dependant on the expression of elements of the BMP pathway.
- Healt Condition(s) or Problem(s) studiedColorectal cancer, Prevention, Statin, Chemotherapy, SMAD4
- Inclusion criteria- Primary diagnosis of colorectal carcinoma between 1st of January 2000 and 31st of December 2007 in the Netherlands and registered in the PHARMO RLS.
- Exclusion criteria- Medical history of colorectal cancer, chemotherapy and/or radiotherapy
- mec approval receivedyes
- multicenter trialyes
- randomisedno
- groupParallel
- Type2 or more arms, non-randomized
- Studytypeintervention
- planned startdate 1-sep-2008
- planned closingdate
- Target number of participants0
- InterventionsNone; molecular analysis
- Primary outcome- Less SMAD4 positive colorectal cancers in Statin users
- Secondary outcome- Survival
- Timepoints- 2 years before diagnosis of CRC until time of diagnosis
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESM.D. PhD fellow R.J. Jacobs
- CONTACT for SCIENTIFIC QUERIESM.D. PhD fellow R.J. Jacobs
- Sponsor/Initiator Leiden University Medical Center (LUMC), Department of Gastroenterology and Hepatology
- Funding
(Source(s) of Monetary or Material Support)
KWF Kankerbestrijding
- PublicationsN/A
- Brief summary
- Main changes (audit trail)
- RECORD20-aug-2008 - 8-sep-2008


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