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Connectivity and networks in epilepsy patients with cranial tumors


- candidate number3914
- NTR NumberNTR1430
- ISRCTNISRCTN wordt niet meer aangevraagd
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR4-sep-2008
- Secondary IDs08/052 METC VU Medisch Centrum
- Public TitleConnectivity and networks in epilepsy patients with cranial tumors
- Scientific TitleFunctional connectivity and neuronal networks in brain tumor patients with epilepsy
- ACRONYMCONNECT
- hypothesis- Epilepsy patients with brain tumours show altered functional connectivity and networks in the brain compared to healthy controls
- Connectivity and networks change over time as a function of treatment
- Healt Condition(s) or Problem(s) studiedBrain tumor, Epilepsy
- Inclusion criteriaInclusion criteria for brain tumor patients:
1. Adult (>18 years)
2. Epilepsy (at least one epileptic seizure)
3. Histopathologically confirmed glioma or meningioma according to the WHO
4. Written informed consent.

Inclusion criteria for healthy controls:
1. Adult (>18 years)
2. Written informed consent.
- Exclusion criteriaExclusion criteria for brain tumor patients:
1. Psychiatric disease or symptoms
2. Insufficient mastery of the Dutch language
3. Inability to communicate adequately.

Exclusion criteria for healthy controls:
1. Use of centrally acting drugs (including analgetics)
2. Psychiatric disease or symptoms
3. Disorders of the central nervous system
4. Insufficient mastery of the Dutch language.
- mec approval receivedyes
- multicenter trialyes
- randomisedno
- group[default]
- Type[default]
- Studytypeintervention
- planned startdate 1-okt-2008
- planned closingdate3-mei-2011
- Target number of participants80
- InterventionsN/A
- Primary outcome- Magnetoencephalography
- Epilepsy diary
- Secondary outcome- Neuropsychological assessment
- TimepointsBaseline, before and after each treatment
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIES Linda Douw
- CONTACT for SCIENTIFIC QUERIES Linda Douw
- Sponsor/Initiator VU University Medical Center
- Funding
(Source(s) of Monetary or Material Support)
Dutch Epilepsy Foundation (NEF)
- PublicationsN/A
- Brief summaryEpilepsy is considered a disease in which dynamic processes in the neuronal networks of the brain are dysfunctional. Patients suffering from primary brain tumors often experience epileptic seizures. Up till now, it is unclear which factors are responsible for the large individual variability in the frequency of epileptic seizures in these patients. Magnetoencephalography (MEG) is an imaging technique that is used for detection of seizure activity and epileptic source localization as well as assessment of functional connectivity and neural network features throughout the brain. Recent research advances concerning functional connectivity and network properties of the brain have indicated that these techniques may be used to investigate factors that determine the frequency of epileptic seizures. Functional connectivity and network structure have also proven to correlate with cognitive functioning in brain tumor patients. The current study aims to investigate whether neural network characteristics of the brain can predict the frequency and severity of epileptic seizures in brain tumor patients. Our secondary objective is to determine the correlation between seizures, network architecture and cognition in this patient group.
- Main changes (audit trail)
- RECORD4-sep-2008 - 16-sep-2008


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