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Influence of different lipid emulsions on glucose uptake and mitochondrial function in healthy adults


- candidate number4258
- NTR NumberNTR1500
- ISRCTNISRCTN wordt niet meer aangevraagd
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR21-okt-2008
- Secondary IDsMEC 05/295 
- Public TitleInfluence of different lipid emulsions on glucose uptake and mitochondrial function in healthy adults
- Scientific TitleEffects of mono-unsaturated and poly-unsaturated fatty acids on insulin sensitivity and mitochondrial function in lean healthy subjects
- ACRONYMIV Lipid study
- hypothesisWe hypothesized that FFA loading could impair mitochondrial function and that the potency of FFA to disturb mitochondrial function and glucose uptake would depend on the degree of desaturation of the fatty acids infused.
- Healt Condition(s) or Problem(s) studiedGlucose metabolism , Diabetes Mellitus, Insuline, Mitochondria
- Inclusion criteria1. Healthy male volunteer
2. Caucasian
3. Age between 18-35 years
4. Normal BMI ( 20-24.9 kg/m2)
5. VO2 max (90-110% predicted value according to Jones formula)
6. Stable weight during 3 months before participation and during participation
7. Normal physical activity with at least 2 times per week sport activities
8. Non-smoking
- Exclusion criteria1. Fasting blood glucose > 5,6 mmol/L or abnormal OGTT (2-hour value after oral ingestion of 75 g, glucose >7.8 mmol/l) Fasting insulin concentration >50 pmol/l
2. BMI> 25 and BMI< 20
3. DM type II in first degree relatives
4. All chronic diseases
5. Drug use
6. Dyslipidaemia
7. Abnormal liver or renal function
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupCrossover
- Type2 or more arms, non-randomized
- Studytypeintervention
- planned startdate 5-dec-2005
- planned closingdate10-feb-2008
- Target number of participants10
- InterventionsInfusion with with to different lipid emulsion respectivily Intralipid® and Clinoleic®, versus Saline. Each patient is his own control.
- Primary outcome- Peripheral glucose uptake (Rd)
- Resting, adp-stimulated and uncoupled mitochondrial respiration rates
- Secondary outcome-Skeletal muscle metabolites of plasma FFA, i.e. glycosphingolipids
- Plasma concentrations of adiponectin, insulin, cortisol, glucagon, catecholamines
- TimepointsParticipants were studied in balanced assignment on three different occasions (each two weeks apart) during a 6 hours infusion of Intralipid ®, Clinoleic®, or saline 0.9% intravenously
- Trial web siteN/A
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIES M. Brands
- CONTACT for SCIENTIFIC QUERIES M.J.M. Serlie
- Sponsor/Initiator Academic Medical Center (AMC), Department of Endocrinology and Metabolism
- Funding
(Source(s) of Monetary or Material Support)
Academic Medical Center (AMC), Department of Endocrinology and Metabolism
- PublicationsN/A
- Brief summaryRecently, disturbed mitochondrial function was shown to be associated with free fatty acid (FFA)- and obesity induced insulin resistance. Different types of FFA can have differential effects on glucose metabolism. Therefore we evaluate the effects of elevated plasma monounsaturated vs. polyunsaturated fatty acids on glucose metabolism and mitochondrial function.
- Main changes (audit trail)
- RECORD21-okt-2008 - 29-okt-2008


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