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An electronic nose in the intensive care investigation of acute lung injury and acute respiratory distress syndrome.


- candidate number4589
- NTR NumberNTR1558
- ISRCTNISRCTN wordt niet meer aangevraagd
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR24-nov-2008
- Secondary IDsAMC20080915.1 METC AMC
- Public TitleAn electronic nose in the intensive care investigation of acute lung injury and acute respiratory distress syndrome.
- Scientific TitleAn electronic nose in the intensive care investigation of acute lung injury and acute respiratory distress syndrome.
- ACRONYMNICI study
- hypothesis1. We postulate that an electronic nose can discriminate exhaled breath of patients with ALI/ARDS lung injury from patients without lung injury and without being at risk for developing lung injury
2. We postulate that an electronic nose can recognize worsening or improvement of lung injury in patients at risk for ALI/ARDS
3. We postulate that an electronic nose can predict the development of ALI/ARDS in patients at risk for ALI/ARDS
- Healt Condition(s) or Problem(s) studiedSepsis, Acute Respiratory Distress Syndrome, Mechanical ventilation, Electronic nose, Ventilation
- Inclusion criteria1. Patients with established ALI/ARDS according to the American/European Consensus Criteria
2. Patients at risk for developing ALI/ARDS
3. Patients without lung injury, not at risk for developing ALI/ARDS and not known to a have pre-existent pulmonary condition
- Exclusion criteria1. Younger than 18 years of age
2. Pregnancy
3. Current malignancy
4. Use of steroids in higher than hysiologic dosages (300 mg hydrocortisone or equivalent)
5. Recent cardiopulmonary surgery (reason for admittance)
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-dec-2008
- planned closingdate1-dec-2009
- Target number of participants150
- InterventionsNo interventions, diagnostic study.
- Primary outcomeElectronic nose smellprint.
Exhaled air is collected via a connector in the circuit of the mechanical ventilator near the tube and, if present, proximal to the filter. The connector is attached to the electronic nose (Cyranose 320) and measurements are taken for 60 seconds.
When exposed to a gas mixture, the sensors of the electronic nose will swell and thus change the electrical conductance, resulting in a unique smellprint.
- Secondary outcome- Lung injury score.
- TimepointsThe electronic nose will measure the exhaled breath of the included patients once every day.
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESM.D. Niki Fens
- CONTACT for SCIENTIFIC QUERIESM.D. Niki Fens
- Sponsor/Initiator Academic Medical Center (AMC), Department of Pulmonology, Academic Medical Center (AMC), Department of Intensive Care
- Funding
(Source(s) of Monetary or Material Support)
Academic Medical Center (AMC), Department of Intensive Care, Academic Medical Center (AMC), Department of Pulmonology
- PublicationsN/A
- Brief summaryCritically ill patients may develop acute lung injury (ALI) or its more severe form acute respiratory distress syndrome (ARDS), which can be the result of either a pulmonary insult (e.g., pneumonia) or indirect injury (e.g., sepsis). Early and adequate recognition of ALI/ARDS is mandatory for intensive care physicians to take sufficient actions at the right time. In today’s intensive care practice, ALI/ARDS is diagnosed and monitored by clinical symptoms, radiology findings and laboratory measurements.
However, diagnosing ALI/ARDS remains challenging. Exhaled breath molecular profiling using electronic nose technology can potentially be usefull in diagnosing as well as monitoring lung injury in mechanically ventilated patients.
- Main changes (audit trail)
- RECORD24-nov-2008 - 15-okt-2009


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