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European Randomized Study of Screening for Prostate Cancer.


- candidate number1261
- NTR NumberNTR156
- ISRCTNISRCTN49127736
- Date ISRCTN created20-dec-2005
- date ISRCTN requested18-okt-2005
- Date Registered NTR29-aug-2005
- Secondary IDsN/A 
- Public TitleEuropean Randomized Study of Screening for Prostate Cancer.
- Scientific TitleEuropean Randomized Study of Screening for Prostate Cancer.
- ACRONYMERSPC
- hypothesisScreening causes a difference in prostate cancer mortality of 20% or more.
- Healt Condition(s) or Problem(s) studiedProstate cancer, Cancer
- Inclusion criteriaMales aging 55-74 (including age 74).
- Exclusion criteriaPrevious diagnosis of prostate cancer.
- mec approval receivedyes
- multicenter trialyes
- randomisedyes
- masking/blindingNone
- controlActive
- groupParallel
- Type-
- Studytypeintervention
- planned startdate 1-okt-1991
- planned closingdate31-dec-2010
- Target number of participants251133
- InterventionsPSA determination followed by DRE and prostate biopsy if PSA >= 3.
- Primary outcomeProstate cancer mortality compared between the screened and the non-screened group of men at risk.
- Secondary outcome1. Progression-free (tumor free) survival;
2. Survival free of metastatic disease;
3. Quality of life in the screened and non-screened populations.
- Timepoints
- Trial web sitehttp://www.erspc.org
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES M. Roobol
- CONTACT for SCIENTIFIC QUERIESProf. Dr. F.H. Schröder
- Sponsor/Initiator Erasmus Medical Center, Department of Urology
- Funding
(Source(s) of Monetary or Material Support)
ZON-MW, The Netherlands Organization for Health Research and Development, Koningin Wilhelmina Fonds (KWF), EU (FP5, FP6)
- PublicationsSee: www.erspc.org
- Brief summaryProstate cancer is the second leading cause of cancer death in men in Western Europe and the United States.
To study whether the effect of early detection and treatment of prostate cancer may reduce the disease-specific mortality a randomized trial is initiated in Europe.
The "European Randomized study of Screening for Prostate Cancer" is a major European effort with 8 participating countries. The study has a co-operation with the Prostate Lung Colonrectal and Ovarian Cancer Screening Trial in the US.
This study should result in advice to governments around the world as to whether screening for prostate cancer should be a part of the general provision of health care to our populations.
- Main changes (audit trail)
- RECORD22-aug-2005 - 15-dec-2006


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