Who are we?


Signup for

Online registration

Log in to register
your trial

Search a trial




van CCT (UK)

van CCT (UK)

Mastication and Quality of life in elderly people suffering from dementia.

- candidate number4598
- NTR NumberNTR1561
- ISRCTNISRCTN wordt niet meer aangevraagd
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR27-nov-2008
- Secondary IDs2504931 VU University Medical Center
- Public TitleMastication and Quality of life in elderly people suffering from dementia.
- Scientific TitleOral health care, increased food consistency and the effects on quality of life, cognition, mood and circadian rhythm in older people with dementia.
- hypothesisIncreased and improved mastication will improve (or, slow down the loss of) cognition, mood and circadian rhythm of elderly people suffering from dementia.
- Healt Condition(s) or Problem(s) studiedDementia, Depression, Physical activity, Cognition, Mastication, Circadian rhythm
- Inclusion criteria1. Older than 50 years; suffering from dementia.
- Exclusion criteria1. History of psychiatric disorder
2. Alcohol abuse
3. Cerebral traumata
4. Normal pressure hydrocephalus
5. Neoplasmata
6. Conscious disorders
- mec approval receivedyes
- multicenter trialyes
- randomisedyes
- masking/blindingSingle
- controlActive
- groupParallel
- Type2 or more arms, non-randomized
- Studytypeintervention
- planned startdate 1-dec-2008
- planned closingdate31-dec-2011
- Target number of participants200
- InterventionsIntervention-Increased masticatory activity achieved through improved oral health care and diet.
- Primary outcomeImproved quality of life.
- Secondary outcomeImprovement of (or, slow down the loss of) cognition, mood and circadian rhythm of elderly people suffering from dementia.
- TimepointsBase line at 0 weeks;
Follow up at 6 weeks, 3 months, and 6 months.
- Trial web site
- statusopen: patient inclusion
- CONTACT for SCIENTIFIC QUERIESDrs. Roxane Weijenberg
- Sponsor/Initiator Vrije Universiteit Amsterdam
- Funding
(Source(s) of Monetary or Material Support)
Innovatiefonds zorgverzekeraars
- PublicationsN/A
- Brief summaryExercise is thought to be beneficial for prevention and treatment of cognitive problems, mood disorders and circadian rhythm disturbances in elderly suffering from dementia.
Improved cardiovascular health and increased brain perfusion are considered to be explanatory mechanisms for this effect.
Mastication induces similar bodily responses as exercise, such as increased heart rate, blood pressure and brain perfusion.
Furthermore, impaired mastication (by means of removal of the molar teeth or by offering soft food) negatively effects the performance of mice in maze tasks, and leads to hippocampal neuron loss. Since the hippocampus is associated with both spatial orientation and memory, these findings indicate that impaired mastication leads to memory loss, amongst others. In humans, correlations have been found between mastication and memory, attention and performance on several executive functioning tasks; i.e. when chewing a piece of gum the performance improves.
- Main changes (audit trail)
- RECORD27-nov-2008 - 11-jun-2012

  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar