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Cardiovascular disease and preeclampsia.


- candidate number5236
- NTR NumberNTR1647
- ISRCTNISRCTN wordt niet meer aangevraagd
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR30-jan-2009
- Secondary IDs08-2-130 MEC
- Public TitleCardiovascular disease and preeclampsia.
- Scientific TitleCardiovascular disease in formerly preeclamptic women.
- ACRONYMN/A
- hypothesisWe hypothise that women with a history of preeclampsia have accelerated vascular aging in comparison with control women with uncomplicated pregnancies.
- Healt Condition(s) or Problem(s) studiedPre-eclampsia, Cardiovascular disease
- Inclusion criteriaParticipation in previous study period 1996-1999. Women with a history of preeclampsia and/or HELLP syndrome. Control women with uncomlicated pregnancies. Previous research within 3 years after pregnancy.
- Exclusion criteriaPre-existent hypertension.
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupParallel
- Type2 or more arms, non-randomized
- Studytypeobservational
- planned startdate 1-mrt-2009
- planned closingdate1-mrt-2011
- Target number of participants30
- InterventionsNone; observational case-control study.
- Primary outcomeRenal vascular resistance.
- Secondary outcomeGlomerular filtration rate, total peripheral vascular resistance, blood pressure, plasma volume, arterial and venous compliance and cardiovascular morbidity.
- TimepointsOne day.
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIES T. Ekhart
- CONTACT for SCIENTIFIC QUERIESDrs. J. Spaan
- Sponsor/Initiator Profileringsfonds, azM
- Funding
(Source(s) of Monetary or Material Support)
Profileringsfonds, azM
- Publications
- Brief summaryPreeclampsia is associated with an increased risk on the development of cardiovascular and renal disease. It seems that similar risk factors are both predictive for preeclampsia and cardiovascular disease. We hypothise that women with a history of preeclampsia have accelerated vascular aging in comparison with controls. Our primary objective is to compare the changes in renal vascular resistance in 10 years between women with a history of preeclampsia and controls. This is a longitudinal case-control study in which 20 formerly preeclamptic women and 10 controls will be included. Those women are recruited from a previous study performed in the period of 1996-1999. The same measurements, including blood pressure, PAH/inulin clearance, plasmavolume, arterial/venous compliance and echocardiography, will be performed.
- Main changes (audit trail)
- RECORD30-jan-2009 - 14-sep-2009


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