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Effects of brain stimulation on metabolism.


- candidate number5577
- NTR NumberNTR1754
- ISRCTNISRCTN wordt niet meer aangevraagd
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR9-apr-2009
- Secondary IDsMETC 08/278  AMC
- Public TitleEffects of brain stimulation on metabolism.
- Scientific TitleEffects of bilateral subthalamic nucleus deep brain stimulation on plasma triglycerides and glucose metabolism.
- ACRONYMDBS PD
- hypothesisBilateral subthalamic nucleus deep brain stimulation gives rise to local changes in the brain with a subsequent effect on hepatic triglyceride secretion and endogenous glucose production.
- Healt Condition(s) or Problem(s) studiedParkinson's disease, Glucose and lipid metabolism disorders
- Inclusion criteriaPatients with parkinsons disease with bilateral subthalamic nucleus deep brain stimulation.
- Exclusion criteria1. Below 18;
2. Psychiatric disorders;
3. Dyslipidemia;
4. Diabetes.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlNot applicable
- groupCrossover
- TypeSingle arm
- Studytypeintervention
- planned startdate 1-jan-2009
- planned closingdate1-dec-2009
- Target number of participants10
- Interventions2 study days which take 8 hours each. Blood withdrawal every hour during 8 hours and within those hours we also perform a hyperinsulinemic euglycemic clamp.
- Primary outcomeGlucose metabolism and lipid metabolism.
- Secondary outcomeHormones.
- TimepointsStart 1-1-2009.
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES B.M. Sondermeijer
- CONTACT for SCIENTIFIC QUERIES B.M. Sondermeijer
- Sponsor/Initiator Academic Medical Center (AMC), Amsterdam
- Funding
(Source(s) of Monetary or Material Support)
Academic Medical Center (AMC)
- PublicationsN/A
- Brief summaryBilateral subthalamic nucleus deep brain stimulation gives rise to local changes in the brain with a subsequent effect on hepatic triglyceride secretion and endogenous glucose production. By turning the stimulator on and off, insight will be given in the effect on the metabolism.
- Main changes (audit trail)
- RECORD9-apr-2009 - 23-sep-2009


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