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Old and well functioning.


- candidate number5968
- NTR NumberNTR1864
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR17-jun-2009
- Secondary IDsNPO 60-61900-98-146 ZonMw
- Public TitleOld and well functioning.
- Scientific TitleOld and well functioning: determinants of preservation of functioning in elderly, a longitudinal observational study.
- ACRONYMPROFIEL
- hypothesisN/A
- Healt Condition(s) or Problem(s) studiedOlder adults, preservation of functioning
- Inclusion criteriaAll participants of the original Frailty- and Hamlet-study:
1. Women (FRAILTY-study): The FRAILTY-study population comprised 402 women between 50 and 74 years of age, living independently in Utrecht and the surrounding area at the time of the baseline visit in 1999-2000. At time of the follow-up visit in 2009-2010 they are 60-84 years of age;
2. Men (HAMLET-study): The HAMLET-study population comprised 400 men between 40 and 80 years of age, living independently in Utrecht at the time of the baseline measurements in 2001-2002. At time of the follow-up visit in 2009-2010 they are 48-88 years of age.
- Exclusion criteriaNone.
- mec approval receivedno
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeobservational
- planned startdate 1-sep-2009
- planned closingdate1-apr-2011
- Target number of participants0
- InterventionsNone.
- Primary outcomePreservation of functioning.
- Secondary outcome1. Isometric Grip Strength (IGS);
2. VO2 max;
3. Physical activity;
4. Physical performance. change in IGS, Physical Performance and Physical Activity
- Timepoints1. Baseline visits 10y ago;
2. Follow-up visits planned for September 2009 until April 2011.
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIESArts Msc E.M.A. Ilse
- CONTACT for SCIENTIFIC QUERIESArts Msc E.M.A. Ilse
- Sponsor/Initiator Julius Center for Health Sciences and Primary Care, Research Group for Nursing and Allied Health care for people with chronic illnesses
- Funding
(Source(s) of Monetary or Material Support)
ZON-MW, The Netherlands Organization for Health Research and Development
- PublicationsN/A
- Brief summaryAccording to the majority of older people preservation of physical and psychosocial functioning is important in their live. However, two third of older people have one or more chronic disease, with a mean number of conditions of 2.5. For older people these chronic conditions become problematic as soon as these conditions threat daily live activities and vitality. Functional decline and loss of vitality can change the balance in daily living negatively with the risk of a cascade breakdown. This group of older people is vulnerable; this vulnerability is often defined as “frailty”. Although frailty is studied in a growing number of studies, the pathway to frailty is almost unknown. Age, disease, loss of muscle mass and bone mineral density are considered as key factors in the process of frailty. The lack of understanding of the physiology and etiology of frailty causes a problem in the development of effective preventive interventions. Preventive interventions could enable people, even in old age and with chronic conditions, to live independently the life they choose to live. Cardiovascular diseases (CVD) such as coronary ischemic disease, heart failure and cerebrovascular accidents are prominent among the chronic conditions that predispose elderly people to functional limitations and disability. Because of the aging of the population, the number of people with functional limitations and disability will only increase.

The aim of this project is to gain insight in which somatic, cognitive and psychosocial factors contribute to preservation of functioning, in order to identify older people with potential risk of functional decline in an early stage and develop interventions to prevent or delay functional decline to enable older people to stay independent and able to take care of themselves.
- Main changes (audit trail)
- RECORD17-jun-2009 - 6-okt-2009


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