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MEG language and memory mapping: a comparison with WADA.


- candidate number6042
- NTR NumberNTR1890
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR30-jun-2009
- Secondary IDs09/124; 09-04; NL26907.029.09;  METc VUmc; CWO VUmc; ABR
- Public TitleMEG language and memory mapping: a comparison with WADA.
- Scientific TitleMEG language and memory mapping: a comparison with WADA.
- ACRONYMMEG-WADA
- hypothesisOur overall aim is to create a cost effective non-invasive method of pre-surgical assessment of language and memory function using MEG scanning. We propose a research project with the key objective to evaluate the effectiveness of a Dutch implementation of a language/memory stimuli and analysis protocol.
- Healt Condition(s) or Problem(s) studiedBrain tumor, Brainsurgery
- Inclusion criteria1. Age between 18 and 85;
2. Has had, or will undergo, a Wada test;
3. Will undergo a MEG and MRI scan as part of a pre-surgical evaluation;
4. Written informed consent.
- Exclusion criteria1. Unable to undergo an MRI scan;
2. Insufficient mastery of the Dutch language;
3. Inability to communicate adequately.
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-jul-2009
- planned closingdate1-jan-2010
- Target number of participants10
- InterventionsLanguage and memory areas will be localised using Magnetoencephalography (MEG). The effectiveness of the protocol will be evaluated by comparison with Wada (intracarotid sodium amobarbital procedure) results.
- Primary outcomeThe raw recorded MEG signals will be post-processed according to standard procedures, and artefact-free epochs will be selected by an experienced investigator. These epochs are then used to localise underlying neuronal activity using an MEG beamformer, in combination with the patientís anatomical MRI. A lateralisation index will be computed on the basis of the reconstructed task-related neuronal power changes. In addition, a lateralisation index will be obtained from the Wada procedure by experienced neuropsychologists who are blinded to the MEG results.
- Secondary outcomeThe lateralisation index computed on the basis of MEG and Wada, respectively, will be compared.
- TimepointsAfter inclusion of the last patient.
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES Alexandra M.E. Linger
- CONTACT for SCIENTIFIC QUERIESDr. Arjan Hillebrand
- Sponsor/Initiator VU University Medical Center
- Funding
(Source(s) of Monetary or Material Support)
VU University Medical Center
- PublicationsN/A
- Brief summaryTo reduce the risk of aphasia or amnesia following surgical resection in patients suffering from epilepsy and/or brain tumours it is necessary to identify language and memory presentation pre-surgically. Of importance here is to determine whether there is a dominant hemisphere with regards to language and memory function. Currently, the gold standard for the evaluation of lateralised language and memory mapping is the Wada procedure. Recent advances in neuroimaging techniques however might provide us with opportunities to replace this invasive procedure with a non-invasive and cost-effective alternative to conduct pre-surgical assessment of language and memory function, and in addition, help in the planning of grid implantations.

Our overall aim is to create a cost effective non-invasive method of pre-surgical assessment of language and memory function using MEG scanning. We propose a research project with the key objective to evaluate the effectiveness of a Dutch implementation of a language/memory stimuli and analysis protocol.
- Main changes (audit trail)
- RECORD30-jun-2009 - 6-okt-2009


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