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Prediction of radiation induced lung damage based on dose distribution and tumour location.


- candidate number6083
- NTR NumberNTR1905
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR10-jul-2009
- Secondary IDsRT2009-06 
- Public TitlePrediction of radiation induced lung damage based on dose distribution and tumour location.
- Scientific TitlePrediction of radiation induced lung damage based on dose distribution and tumour location.
- ACRONYMN/A
- hypothesisTo investigate the newly developed method to study lung density changes using CT-scan, in a small patient population.

The relationship between radiation induced lung density changes and dose distribution/tumor location will be investigated.
- Healt Condition(s) or Problem(s) studiedRadiotherapy, Lung
- Inclusion criteria1. Age > 18 years;
2. WHO PS 0-2;
3. Stage IIIA/IIIB Non Small Cell Lung Cancer (NSCLC);
4. Limited disease Small Cell Lung Cancer;
5. Adequate pulmonary lung function;
6. Life expectancy of at least 6 months.
- Exclusion criteria1. WHO PS=3;
2. Life expectancy < 6months.
- mec approval receivedno
- multicenter trialno
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-sep-2009
- planned closingdate1-sep-2010
- Target number of participants20
- InterventionsResearch CT-scans are performed prior to and 6, 24, 52 weeks after completion of treatment. This time course covers acute radiation pneumonitis (6-26 weeks after treatment) and the development of radiation induced lung fibrosis (26 weeks and onwards).
- Primary outcomeDensity changes measured with serial CT-scans scored using the newly developed quantification method.
- Secondary outcome1. The regional dependency of structural lung damage (tumor location);
2. The relationship between lung density changes and dose distribution;
3. The dynamics of structural lung damage (density changes) in time.
- TimepointsResearch CT-scans are performed prior to and 6, 24, 52 weeks after completion of treatment.
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIES
- CONTACT for SCIENTIFIC QUERIES
- Sponsor/Initiator
- Funding
(Source(s) of Monetary or Material Support)
UMC Groningen, Department of radiation oncology
- PublicationsN/A
- Brief summaryN/A
- Main changes (audit trail)
- RECORD10-jul-2009 - 10-okt-2009


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