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De rol van genetische aanleg in het effect van groene thee op vetoxidatie en het energiegebruik.

- candidate number6119
- NTR NumberNTR1918
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR20-jul-2009
- Secondary IDsMEC 09-3-003 MEC Unimaas
- Public TitleDe rol van genetische aanleg in het effect van groene thee op vetoxidatie en het energiegebruik.
- Scientific TitleThe role of genetic predisposition in the effect of green tea on fat oxidation and energy expenditure.
- ACRONYMGreen tea and polymorphisms
- hypothesisWe hypothesize that subjects (Asian or Caucasian) with the COMTH allele (Val/Val polymorphism) respond stronger to the GT treatment than subjects with the COMTL allele (Met/Met polymorphism), consequently have an increased EE and that the genetic differences between Asians and Caucasians are responsible for the different outcomes in GT studies with both subjects.
- Healt Condition(s) or Problem(s) studiedObesity
- Inclusion criteria1. Healthy;
2. Asian and Caucasian men and women;
3. A Body Mass Index (BMI) between 18-25 kg/m2;
4. Age of 18-50 years;
5. They must have either a COMTH allele or a COMTL allele.
- Exclusion criteriaExclusion criteria for subjects are apart from age, BMI, origin and polymorphisms:
1. Smoking;
2. Being on medication (except the use of contraception);
3. Excessive alcohol consumption;
4. Excessive exercise;
5. Not being weight stable;
6. Being dietary restraint (assessed by the Three Eating Questionnaire (TFEQ));
7. People who drink more than one cup of coffee per day.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingSingle
- controlPlacebo
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 15-sep-2009
- planned closingdate10-sep-2011
- Target number of participants48
- InterventionsAll subjects spent 2 x 36 hours in randomized order in a respiration chamber on the university. On one of these occasions subjects receive green tea (757 mg/capsule) next to their meals, during the other visit the subjects will receive a placebo instead of tea. All subjects are randomly exposed to both treatments.
- Primary outcome1. Effect of green tea on : Energy expenditure and fat oxidation;
2. Feelings of hunger and satiety measured with visual analogue scales;
3. Effects of different polymorphisms in people with different ethnicity on the utcome of energy expenditure and substrate oxidation after supplementation with green tea.
- Secondary outcomeNo secondary outcomes.
- TimepointsOne test arm will last for 36 hours. In total both test arms will last for 72 hours. Hunger and satiety are measured every hour from 08.00 AM till 11.00 PM.
- Trial web siteN/A
- statusplanned
- Sponsor/Initiator University Maastricht (UM)
- Funding
(Source(s) of Monetary or Material Support)
University Maastricht (UM)
- PublicationsN/A
- Brief summaryPrevious studies have shown that green tea enhances thermogenesis and fat oxidation. However, differences in outcome between Asian and Caucasian studies suggests that their might be a genetical factor thet influences the thermogenic effect. Differences in allelefrequencies of the enzyme COMT, the main target of catechins in green tea, between populations might underlie the different response to tea between subjects.
- Main changes (audit trail)
- RECORD20-jul-2009 - 10-okt-2009

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