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Metabolic effects of deep brain stimulation in patients with obsessive compulsive disorder.


- candidate number6438
- NTR NumberNTR2000
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR10-sep-2009
- Secondary IDsMEC 08/276 METC Academic medical center
- Public TitleMetabolic effects of deep brain stimulation in patients with obsessive compulsive disorder.
- Scientific TitleMetabolic effects of deep brain stimulation in patients with obsessive compulsive disorder.
- ACRONYMDBS-OCD
- hypothesisDeep brain stimulation influences the HPA axis and glucose- and lipid metabolism in patients with obsessive compulsive disorder (OCD).
- Healt Condition(s) or Problem(s) studiedDiabetes Mellitus Type 2 (DM type II), Obsessive-compulsive disorder (OCD), Insulin resistance
- Inclusion criteriaPatients with OCD with deep brain stimulation in the nucleus accumbens.
- Exclusion criteria1. Use of psychotropic drugs;
2. Use of drugs or abuse;
3. Pregnancy;
4. Use of medication known to interfere with glucose or lipid metabolism;
5. DMII or impaired fasting glucose;
6. Primary lipid disorder;
7. Performance of vigorous exercise;
8. Renal insufficiency or elevated liver enzymes.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlActive
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 10-jan-2009
- planned closingdate10-jan-2010
- Target number of participants16
- InterventionsHyperinsulinemic euglycemic clamp with stable isotopes.
- Primary outcome1. HPS axis activity;
2. Endogenous glucose production.
- Secondary outcome1. Lipid metabolism;
2. Resting energy expenditure.
- TimepointsN/A
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES N.M. Lammers
- CONTACT for SCIENTIFIC QUERIES M.J.M. Serlie
- Sponsor/Initiator Academic Medical Center (AMC), Department of Endocrinology and Metabolism
- Funding
(Source(s) of Monetary or Material Support)
Academic Medical Center (AMC), Department of Endocrinology and Metabolism
- PublicationsN/A
- Brief summaryCentral regulation of glucose- and lipid metabolism is an area of research in the field of obesity and insulin. Especially the nucleus accumbens has become an area of interest, because of its involvement in food intake, satiety and energy expenditure. It has been shown that dopamine metabolism in the mesoaccumbens system may be altered in obesity with contradictory rsults showing either reduced or increased dopamine signaling. The procedure of DBS in de nucleus accumbens provides an exceptional opportunity to gain insight in the role of the nucleus accumbens in these metabolic processes.
We will perform a hyperinsulinemic euglycemic clamp with stable isotopes in the off and on situation, to measure glucose- and lipid metabolism and use plasma ACTH and urine cortisol levels to measure HPA axis activity.
- Main changes (audit trail)
- RECORD10-sep-2009 - 12-okt-2009


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