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Lipid-induced insulin resistance.


- candidate number6444
- NTR NumberNTR2002
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR10-sep-2009
- Secondary IDs06-3-049 METC Maastricht University Medical Center
- Public TitleLipid-induced insulin resistance.
- Scientific TitleLipid-induced insulin resistance in Endurance-trained and untrained men.
- ACRONYMN/A
- hypothesisAdministration of a lipid emulsion consisting of long-chain triglycerides (LCT-trial) in non-trained individuals, will induce insulin resistance due to increased DAG accumulation and subsequent activation of the PKC pathway in skeletal muscle. Infusion of long-chain triglycerides (LCT-trial) in endurance-trained subjects will result in no -or less pronounced- insulin resistance, because of a better capacity to mobilize and/or oxidize fatty acids. In case of infusion of medium-chiain triglycerides (MCT-trial), the induction of insulin resistance will be absent for both, trained- and non-trained subjects.
- Healt Condition(s) or Problem(s) studiedInsulin resistance, Mitochondrail function
- Inclusion criteria1. Male sex;
2. Age 18-35 years;
3. BMI < 25 kg/m2;
4. Stable dietary habits.
- Exclusion criteria1. Family history of diabetes;
2. Medication use.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlActive
- groupCrossover
- Type2 or more arms, non-randomized
- Studytypeintervention
- planned startdate 8-feb-2006
- planned closingdate30-sep-2009
- Target number of participants20
- InterventionsAll subjects will undergo three hyperinsulinemic euglycemic clamps, in a random order, with simultaneous infusion of either glycerol (control trial), LCT or MCT/LCT.
- Primary outcomeInsulin sensitivity (hyperinsulinemic-euglycemic clamp) and mitochondrial function.
- Secondary outcome1. Whole body oxidative capacity;
2. Body composition;
3. Skeletal muscle mitochondrial markers;
4. Muscle lipid accumulation;
5. Expression of proteins involved in fatty acid handling;
6. Insulin signalling in skeletal muscle.
- TimepointsThe clamps will be separated by at least 1 week in each subject.
- Trial web siteN/A
- statusstopped
- CONTACT FOR PUBLIC QUERIESDr. Patrick Schrauwen
- CONTACT for SCIENTIFIC QUERIESDr. Patrick Schrauwen
- Sponsor/Initiator University Hospital Maastricht (AZM)
- Funding
(Source(s) of Monetary or Material Support)
Diabetes Fund, Amersfoort, the Netherlands
- PublicationsN/A
- Brief summaryN/A
- Main changes (audit trail)
- RECORD10-sep-2009 - 12-okt-2009


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