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The Staphylococcus aureus bacteria with insensitivity for methicillin antibiotics: a search for new risk factors and renewel of the guidelines / De Staphylococcus aureus bacterie met ongevoeligheid voor meticilline antibiotica: Een zoektocht naar nieuwe risicofactoren en vernieuwing van de richtlijnen.


- candidate number6546
- NTR NumberNTR2041
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR1-okt-2009
- Secondary IDs50-50800-98-085 / MEC-2009-415 ZonMW / METC ErasmusMC
- Public TitleThe Staphylococcus aureus bacteria with insensitivity for methicillin antibiotics: a search for new risk factors and renewel of the guidelines / De Staphylococcus aureus bacterie met ongevoeligheid voor meticilline antibiotica: Een zoektocht naar nieuwe risicofactoren en vernieuwing van de richtlijnen.
- Scientific TitleMRSA of Unknown Origin: Risk Assessment and Adjustment of Risk Classification.
- ACRONYMMUO
- hypothesisThe current rise of CA-MRSA in the Netherlands is due to them all being MRSA of Unknown Origin (MUO). We do not know the risk factors yet of these. If we do, the CA-MRSA will drop.
- Healt Condition(s) or Problem(s) studiedMRSA (Meticillin Resistant Staphylococcus aureus), CA-MRSA
- Inclusion criteriaMRSA send by the laboratory to the RIVM. Inclusion based on being a MUO by routine questionnaire.
- Exclusion criteriaCase with (severely) incomplete background epidemiological data.
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeobservational
- planned startdate 1-jul-2009
- planned closingdate1-jul-2013
- Target number of participants600
- InterventionsNone.
- Primary outcomeDevelopment of a new algorithm. Implementation of the new algorithm by the HCC’s and public health. Evaluation of the algorithm is done by comparing the rate of MRSA carriers characterized as belonging to one of the defined risk groups (including new ones), to the rate of MRSA defined as MUO. If this study identified significant risk groups and implementation of this knowledge is sufficient, the risk group rate will increase over time.
- Secondary outcomeA found difference in characteristics (phenotype, profiling, genetics) for MUO (MRSA) strains.
- TimepointsNo interim analysis needed/planned.
- Trial web siteN/A
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIES W.S.N. Lekkerkerk
- CONTACT for SCIENTIFIC QUERIES W.S.N. Lekkerkerk
- Sponsor/Initiator Erasmus Medical Center, Department of Medical Microbiology and Infectious Disease, Rijksinstituut voor Volksgezondheid en Milieu (RIVM)
- Funding
(Source(s) of Monetary or Material Support)
ZON-MW, The Netherlands Organization for Health Research and Development
- PublicationsN/A
- Brief summary The Erasmus MC, department of Medical Microbiology and Infectious diseases has teamed up with the Center of Infectious Disease Control of the RIVM for a new research project. The research project is about MRSA of Unknown Origin: MUO – Risk Assessment and Adjustment of Risk Classification. The research team, under guidance of M.C.Vos (ErasmusMC) and N. van de Sande (CIb/EPI), will try to sort out what causes an alarming rise of MRSA-prevalence outside the healthcare facilities, presumably due to unknown sources. This rise consists out of carriers without known risk factors, who fall outside our described risk categories in the WIP guideline. This could be a threat to our successful Search&Destroy policy. The aim of the research is to find an explanation for the presence of MUO in people without known risk factors for MRSA carriage. If a reason is found, this will result in adaptation of the current guidelines. This study is financed by ZonMW (government).
- Main changes (audit trail)8-Apr-2014: Studie afgerond. - AB
- RECORD1-okt-2009 - 8-apr-2014


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