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Predicting growth and curve progression in the individual patient with adolescent idiopathic scoliosis.


- candidate number6564
- NTR NumberNTR2048
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR8-okt-2009
- Secondary IDs0716 STW
- Public TitlePredicting growth and curve progression in the individual patient with adolescent idiopathic scoliosis.
- Scientific TitlePredicting growth and curve progression in the individual patient with adolescent idiopathic scoliosis.
- ACRONYM
- hypothesisGoal is to develop an algorithm for determination of the timing and magnitude of the peak growth velocity in the individual patient with adolescent idiopathic scoliosis.
- Healt Condition(s) or Problem(s) studiedAdolescent idiopathic scoliosis (AIS)
- Inclusion criteriaAll patients between 8 and 18 years, with adolescent idiopathic scoliosis (Cobb angle >10o) visiting the outpatient clinic of the UMCG.
- Exclusion criteria1. Previous spinal operation;
2. Skeletal dysplasia;
3. Abnormalities of maturation or height that would influence height measurements.
- mec approval receivedno
- multicenter trialno
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeobservational
- planned startdate 11-nov-2009
- planned closingdate11-nov-2012
- Target number of participants40
- InterventionsThis study is primarily observational. Several growth parameters are measured and observed in order to determine the relationship with the peak growth velocity and the scoliosis progression.
Parameters are: Measurement of height, sitting height, leg length, lateral armspan, foot length, shoe size, weight. Determination of secondary sexual characteristics. Measurement of EMG ratios of the paraspinal muscles. Determination of skeletal age in the hand, elbow, and pelvis. Status of the triradiate cartilage, Risser sign. Follow up of the Cobbe angle, the rotations in the spine, and the length of teh scoliotic spine.
- Primary outcomeAn algorithm for determination of the timing and magnitude of the peak growth velocity in the individual patient with adolescent idiopathic scoliosis.
- Secondary outcomeThe relationship of several growth parameters to the peak growth velocity of height and the progression of the idiopathic scoliosis.
- TimepointsAll the growth parameters are measured every 6 months at regular follow up of the idiopathic scoliosis.
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIESProf. Dr. A.G. Veldhuizen
- CONTACT for SCIENTIFIC QUERIESProf. Dr. A.G. Veldhuizen
- Sponsor/Initiator University Medical Center Groningen (UMCG), Department Orthopaedic Surgery
- Funding
(Source(s) of Monetary or Material Support)
University Medical Center Groningen (UMCG), Department Orthopaedic Surgery
- PublicationsPredicting growth and curve progression in the individual patient with adolescent idiopathic scoliosis: design of a prospective longitudinal cohort study. Submitted to BMC Musculoskeletal disease October 2009.
- Brief summaryThe goal of this study is to develop an algorithm for predicting the timing and magnitude of the peak growth velocity in the individual patient with adolescent idiopathic scoliosis. The predictive value is determined of several maturity indicators that reflect growth or remaining growth potential. examples are different length measurements, secondary sexual characteristics, skeletal age in different areas, and EMG measurements of the paraspinal muscles. Furthermore, these parameters are evaluated for their correlation with curve progression in the individual scoliosis patient.
- Main changes (audit trail)
- RECORD8-okt-2009 - 29-okt-2009


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