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Lipid-induced mitochondrial dysfunction in type 2 diabetes.


- candidate number6630
- NTR NumberNTR2074
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR22-okt-2009
- Secondary IDs04-257 METC Maastricht University Medical Center
- Public TitleLipid-induced mitochondrial dysfunction in type 2 diabetes.
- Scientific TitleSkeletal Muscle Insulin Resistance: potential mechanisms and effect of weight-loss and exercise.
- ACRONYM
- hypothesisDoes lipid accumulation in skeletal muscle and the heart effect mitochondrial function in relation to insulin resistance?
- Healt Condition(s) or Problem(s) studiedDiabetes Mellitus Type 2 (DM type II), Insulin resistance, Mitochondrail function
- Inclusion criteria1. Well controlled type 2 diabetic patients;
2. Normoglycemic first-degree relatives with at least one first-line family member diagnosed with type 2 diabetes;
3. Normoglycemic control subjects;
4. BMI 27 - 30 kg/m2;
5. Age 50- 70 y.
- Exclusion criteria1. Uncontrolled hypertension;
2. Active cardiovascular disease;
3. Liver disfunction;
4. Medication known to interfere with glucose metabolism (except for diabetic patients).
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupParallel
- TypeSingle arm
- Studytypeobservational
- planned startdate 2-jan-2005
- planned closingdate31-dec-2009
- Target number of participants60
- InterventionsNo intervention is performed.
- Primary outcome1. Ex vivo mitochondrial function;
2. In vivo mitochondrial function;
3. Insulin sensitivity;
4. Fat accumulation in muscle and heart;
5. Indirect calorimetry.
- Secondary outcome1. Plasma glucose;
2. Plasma insulin;
3. Plasma free fatty acids;
- Timepoints1. All metabolic measurements for one patient planned within one month. 2. All subjects underwent these metabolic measurements within 1.5 year.
- Trial web siteN/A
- statusstopped
- CONTACT FOR PUBLIC QUERIESDr. Patrick Schrauwen
- CONTACT for SCIENTIFIC QUERIESDr. Patrick Schrauwen
- Sponsor/Initiator Maastricht University Medical Center (MUMC+)
- Funding
(Source(s) of Monetary or Material Support)
Diabetes Fund, Amersfoort, the Netherlands
- PublicationsLower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients.
Diabetes, VOL 57, November 2008.
- Brief summaryWe found a reduced basal ADP-stimulated and maximal mitohondrial respiratory capacity related to type 2 diabetes, which underlies the reduction in in vivo mitochondrial function, independent of mitochondrial content.
- Main changes (audit trail)
- RECORD22-okt-2009 - 31-okt-2009


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