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Preoperative strength training for patients awaiting total knee arthroplasty.


- candidate number7901
- NTR NumberNTR2278
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR1-apr-2010
- Secondary IDs10.01 / 30715 ; CWO MOVE / ABR Nummer
- Public TitlePreoperative strength training for patients awaiting total knee arthroplasty.
- Scientific TitleThe effects of additional intensive preoperative strength training on preoperative strength, voluntary activation and functional tasks, and postoperative recovery for patients awaiting total knee arthroplasty.
- ACRONYMPITSTOP
- hypothesis95% of the patients undergoing total knee arthroplasty are diagnosed with osteoarthritis. Osteoarthritis is a joint disease which is characterized by pain, loss of force and problems during activities of daily life. This can result in reduced social participation and quality of life. Current advice on preoperative training is very diverse. Some hospitals advise patient to consult a physiotherapist before surgery, while others do not. Between physiotherapists there are large differences in treatment. While some only train walking with aids, others perform intensive strength training. Because there is evidence that intensive strength training is beneficial post surgery, our hypothesis is that preoperative training also leads to increases in muscle strength, voluntary activation, and physical functioning. Further we expect to find indications that positive preoperative effects promote postoperative recovery. This study can help to shorten recovery and increase the quality of life for patients undergoing total knee arthroplasty.
- Healt Condition(s) or Problem(s) studiedTotal knee replacement (TKR), Rehabilitation, Arthrosis
- Inclusion criteria1. Minimum age of 55 yrs;
2. On the waiting list for unilateral TKA.
- Exclusion criteria1. Contraindications for training the lower limbs;
2. ASA>2 (American Society of Anesthesiologists);
3. Severe cognitive and/or communicative problems, preventing ability to follow verbal instructions;
4. Other problems that would limit the ability to perform the requested tasks;
5. Contra-indications for electrical stimulation (unstable epilepsy, cancer, skin abnormalities, pacemaker).
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingSingle
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-jul-2010
- planned closingdate1-sep-2012
- Target number of participants80
- Interventions1. Control group: Usual care according to guidelines for training subjects with osteoarthritis;
2. Intervention group: Usual care plus additional intensive strength training (6 weeks 2 days a week). The strength training consist of 4 legexercises. The number of repeats decreases from 15 to 8, but weight increases.

After surgery, both groups will receive the same exercise program.
- Primary outcome1. Isometric knee extension force;
2. Voluntary activation of the quadriceps.
- Secondary outcome1. Cross sectional area of the quadriceps;
2. Flexor strength;
3. Range of motion of the knee;
4. Time for the “five times sit to stand test”;
5. Distance walked during the “six minute walk test”;
6. Time for the stair climb test;
7. Time for the balance test;
8. Scores at the WOMAC questionnaire and VAS pain scale will be used for assessment of quality of life.
- TimepointsAll variables will be measured at:
1. 6 weeks before surgery;
2. 0 weeks before surgery;
3. 5 weeks after surgery;
4. 12 weeks after surgery.
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIES D.M. Leeuwen, van
- CONTACT for SCIENTIFIC QUERIES D.M. Leeuwen, van
- Sponsor/Initiator VU Faculty of Human Movement Sciences
- Funding
(Source(s) of Monetary or Material Support)
VU University Medical Center
- PublicationsN/A
- Brief summary95% of the patients undergoing total knee arthroplasty are diagnosed with osteoarthritis. Osteoarthritis is a joint disease which is characterized by pain, loss of force and problems during activities of daily life. This can result in reduced social participation and quality of life. Current advice on preoperative training is very diverse. Some hospitals advise patient to consult a physiotherapy pre surgery, while others do not. Between physiotherapists there are huge differences in treatment. While some only train walking with aids, others perform intensive strength training. Because there is evidence that intensive strength training is beneficial post surgery, our hypothesis is that preoperative training also leads to increases in muscle strength, voluntary activation, and physical functioning. Further we expect to find indications that positive training status is related to postoperative recovery.
- Main changes (audit trail)
- RECORD1-apr-2010 - 11-apr-2011


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