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Cerebral blood flow measurements with fMRI.


- candidate number8040
- NTR NumberNTR2318
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR4-mei-2010
- Secondary IDs09/248 METC AMC
- Public TitleCerebral blood flow measurements with fMRI.
- Scientific TitleThe effect of a liquid meal on cerebral lood flow in healthy lean individuals measured with (1 tesla) fMRI: A pilot study.
- ACRONYM
- hypothesisThe response in cerebral blood flow upon ingestion of a liquid meal differs between males and females.
- Healt Condition(s) or Problem(s) studiedfMRI, Liquid meal, Cerebral blood flow
- Inclusion criteria1. 15 lean male subjects/ 15 lean female subjects;
2. BMI 20- 25 kg/m;
3. Age 18 60 years;
4. Stable weight 3 months prior to study inclusion;
5. Caucasian;
6. Written informed consent;
7. Right handed.
- Exclusion criteria1. Claustrophobia;
2. Metal objects in the body (e.g. pacemaker);
3. Left handed;
4. Smoking and/or Alcohol/Drug abuse;
5. Intensive exercise (more than 3 times per week);
6. Eating disorder (other DSM IV diagnosis);
7. Medication use that interferes with dopamine metabolism or nutrient absorption;
8. DM.
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupParallel
- TypeSingle arm
- Studytypeintervention
- planned startdate 1-mei-2010
- planned closingdate1-mei-2011
- Target number of participants30
- InterventionsIngestion of a high-caloric liquid meal.
- Primary outcomePercentage and/or absolute changes in local cerebral blood flow after a liquid meal.
- Secondary outcome1. Difference in cerebral blood flow between males and females;
2. Influence of ingestion of a liquid meal.
- TimepointsOne measurement (fMRI).
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESMD B.A.M. Weijer, de
- CONTACT for SCIENTIFIC QUERIES M.J.M. Serlie
- Sponsor/Initiator Academic Medical Center (AMC), Amsterdam
- Funding
(Source(s) of Monetary or Material Support)
Academic Medical Center (AMC)
- PublicationsN/A
- Brief summaryThe brain is the master regulator of food intake. It has been shown that there are anatomical differences between certain brain areas in obese compared with lean people. Also, the response to food related ques seems to be different between these groups. The latter can be studied by measuring cerebral blood flow with fMRI.
- Main changes (audit trail)
- RECORD4-mei-2010 - 23-mei-2010


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