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Respiratory system mechanics and electrical impedance tomography measurements during mechanical ventilation with heliox in infants with respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD).


- candidate number1412
- NTR NumberNTR235
- ISRCTNISRCTN98152468
- Date ISRCTN created20-dec-2005
- date ISRCTN requested18-okt-2005
- Date Registered NTR6-sep-2005
- Secondary IDsN/A 
- Public TitleRespiratory system mechanics and electrical impedance tomography measurements during mechanical ventilation with heliox in infants with respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD).
- Scientific TitleRespiratory system mechanics and electrical impedance tomography measurements during mechanical ventilation with heliox in infants with respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD).
- ACRONYMN/A
- hypothesisFirst, mechanical ventilation with a gas mixture composed of helium and oxygen is only beneficial in patients with obstructive RSV LRTD. Hence correct identification of the clinical phenotype is necessitated. This can be done with lung function testing, including compliance and resistance. Second, the beneficial effect of heliox can be detected with repeated EIT measurements.
- Healt Condition(s) or Problem(s) studiedRespiratory Syncytial Virus (RSV), Lower Respiratory Tract Disease (LRTD)
- Inclusion criteriaMechanically ventilated infants younger than 12 months of age with a virologically proven RSV infection.
- Exclusion criteriaOlder than 12 months of age, no informed consent, prior use of corticosteroids, infants on high-frequency oscillatory ventilation and infant wit a haemodynamically significant congenital heart defect.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlActive
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-okt-2005
- planned closingdate1-apr-2007
- Target number of participants15
- InterventionsMechanical ventilation with heliox.
- Primary outcomeRespiratory system mechanics (compliance and resistance).
- Secondary outcomeArterial pCO2.
- Timepoints
- Trial web siteN/A
- statusinclusion stopped: follow-up
- CONTACT FOR PUBLIC QUERIESDr. M.C.J. Kneyber
- CONTACT for SCIENTIFIC QUERIESDr. M.C.J. Kneyber
- Sponsor/Initiator VU University Medical Center
- Funding
(Source(s) of Monetary or Material Support)
None
- PublicationsN/A
- Brief summaryN/A
- Main changes (audit trail)
- RECORD6-sep-2005 - 27-nov-2009


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