search  
 


Home

Who are we?

Why
register?


Signup for
registration


Online registration

Log in to register
your trial


Search a trial

NRT en CCMO

Contact

NEDERLANDS





MetaRegister
van CCT (UK)


ISRCTN-Register
van CCT (UK)


MRI investigation of blood flow and regulation to the brain by the neck vessels.


- candidate number8515
- NTR NumberNTR2541
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR30-sep-2010
- Secondary IDs2010-022875-70 EudraCT
- Public TitleMRI investigation of blood flow and regulation to the brain by the neck vessels.
- Scientific TitleMR Imaging of cerebral blood flow and autoregulation in patients with steno-occlusive vertebro-basilar artery disease.
- ACRONYM
- hypothesisThe primary objective will be to assess whether cerebrovascular reactivity is impaired in the perfusion territory of the vertebrobasilar artery in symptomatic patients with steno-occlusive disease.
- Healt Condition(s) or Problem(s) studiedSteno-occlusive disease of the vertebral and basilar artery
- Inclusion criteria1. 18 years or older;
2. Patients with ischaemic stroke or TIA in the perfusion territory of the vertebo-basilar arteries.
- Exclusion criteria1. Pregnancy or possible pregnancy;
2. Implanted stent(s);
3. Severe liver or renal dysfunction;
4. Addison’s disease;
5. Allergic reaction for sulfonamides;
6. Cor pulmonale;
7. Longobstruction / emfysema;
8. Primary hyperaldosteronisme;
9. Fenytoïne, primidon and/or fenobarbital use;
10. Japanese and Indian subjects or subjects of Japanese descent;
11. Impossibility to undergo MRI (claustrophobia, metal objects in or around the body).
- mec approval receivedno
- multicenter trialno
- randomisedno
- groupParallel
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-jan-2011
- planned closingdate31-dec-2013
- Target number of participants100
- InterventionsNo intervention is applicable.
- Primary outcomeThe primary outcome is cerebrovascular reactivity measured with MR imaging at 3 Tesla using a visual stimulus and administration of vasodilatory challenge medication to induce hemodynamic stress.
- Secondary outcomeSecondary outcomes include cerebral blood flow and perfusion territories of the brain feeding arteries.
- TimepointsWithin one year of onset of clinical symptoms.
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIESMD. MSc. N.S. Hartkamp
- CONTACT for SCIENTIFIC QUERIESMD. MSc. N.S. Hartkamp
- Sponsor/Initiator University Medical Center Utrecht, Department of Radiology
- Funding
(Source(s) of Monetary or Material Support)
University Medical Center Utrecht, Department of Radiology
- PublicationsN/A
- Brief summaryIn patients with ischaemic stroke and steno-occlusive disease of the vertebrobasilar artery it is difficult to assess which patients are at risk for future stroke and should be treated with an endovascular or surgical procedure. An important parameter that can predict such events is the cerebrovascular reactivity, the vasodilatory response of the cerebral resistance vessels. The global increase of cerebral blood flow under conditions of hemodynamic stress is a measure of the cerebrovascular reactivity.
The primary objective will be to assess whether cerebrovascular reactivity is impaired in the perfusion territory of the vertebrobasilar artery in symptomatic patients with steno-occlusive disease.
- Main changes (audit trail)
- RECORD30-sep-2010 - 8-okt-2010


  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar nederlands@trialregister.nl