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Composition of IVF culture media affects birth weight by differential epigenetic effects in placental tissue.


- candidate number8956
- NTR NumberNTR2698
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR17-jan-2011
- Secondary IDs09-4-057 MEC azM/UM
- Public TitleComposition of IVF culture media affects birth weight by differential epigenetic effects in placental tissue.
- Scientific TitleComposition of IVF culture media affects birth weight by differential epigenetic effects in placental tissue.
- ACRONYMN/A
- hypothesisCulture media used for human IVF induce epigenetic deregulation of imprinted genes in placental and/or fetal tissue, which results in a reduced birth weight.
- Healt Condition(s) or Problem(s) studiedSubfertility, Epigenetics
- Inclusion criteria1. Patients pregnant after IVF or IVF with ICSI where one of the two tested culture media systems is used (i.e. participants in trial NTR1979);
2. Only pregnancies following fresh transfer;
3. Only singleton pregnancies.
- Exclusion criteriaUsage of donor gametes.
- mec approval receivedyes
- multicenter trialyes
- randomisedno
- groupParallel
- Type2 or more arms, non-randomized
- Studytypeobservational
- planned startdate 1-feb-2011
- planned closingdate1-feb-2015
- Target number of participants128
- InterventionsTwo commercially available culture media are used for the embryo culture in IVF treatment.
- Primary outcomeRate of methylation and expression of imprinted genes. Gene expression will be analysed using a quantitative real-time PCR method. For the methylation analysis, the DNA will be treated with bisulphite and subsequently pyrosequencing will be used to quantitatively analyse the methylation level of the regions of interest.
- Secondary outcomeCorrelation between methylation and expression of imprinted genes and birth weight.
- TimepointsThe duration of the study is 4 years.
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES A. Montfoort, van
- CONTACT for SCIENTIFIC QUERIES A. Montfoort, van
- Sponsor/Initiator Maastricht University Medical Center (MUMC+)
- Funding
(Source(s) of Monetary or Material Support)
Maastricht University Medical Center (MUMC+)
- PublicationsN/A
- Brief summaryThis study investigates whether the culture medium used in human IVF has an effect on the epigenetic regulation in placental and fetal tissue.
- Main changes (audit trail)
- RECORD17-jan-2011 - 6-feb-2011


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