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van CCT (UK)


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van CCT (UK)


The effect of computer reminders on prescribing behaviour of GPs.


- candidate number1465
- NTR NumberNTR270
- ISRCTNISRCTN16576123
- Date ISRCTN created20-dec-2005
- date ISRCTN requested18-okt-2005
- Date Registered NTR8-sep-2005
- Secondary IDsN/A 
- Public TitleThe effect of computer reminders on prescribing behaviour of GPs.
- Scientific TitleThe effect of computer reminders on prescribing behaviour of GPs.
- ACRONYMN/A
- hypothesisWe hypothesised that this strategy could lead to a considerable and relevant change of prescribing behaviour in the desired direction.
- Healt Condition(s) or Problem(s) studied
- Inclusion criteriaOne inclusion criterion for inviting GPs to the intervention was using a specific medical information system for GPs called MicroHis.
- Exclusion criteriaN/A
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingSingle
- controlActive
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-okt-2003
- planned closingdate1-okt-2006
- Target number of participants53
- InterventionsA clustered RCT with incomplete block design was executed in the Maastricht and Eastern-South Limburg region.
Randomisation took place on practice level into 2 blocks: 25 GPs received reminders on antibiotics and asthma/COPD prescriptions, 28 GPs received reminders on cholesterol prescriptions. All GPs were told that they were participating in a trial, but they were blind for the fact that they only received part of the prescribing reminders.
A computer-reminder-system with reactive reminders was developed to lead to a change in prescribing behaviour in the desired direction. All relevant prescription was written to a special database. GPs were obliged to register a diagnosis for all patients with asthma/COPD, cholesterol related disease or infections for which antibiotics were prescribed. The diagnosis, anamnesis, prescription information as well as information about the patient and GP in question was written to this database.
The character of the reminders could be less or more persuasive and contained various types of reminders: alternative type of drugs, other doses, alternative drug administration, specific indication, other length of prescribing, not to prescribe anything or refer to specialist.
The guidelines on which the reminders were based were developed by multidisciplinary expert teams. The topics were selected because of high prevalence of the health problems and contained antibiotics, asthma/COPD related drugs and cholesterol lowering drugs.
- Primary outcomeThe central measure in our trial:
prescription according to the guideline recommendation as a percentage of total prescriptions of that drug in block A and B.
- Secondary outcomeOther measures are: absolute number of reminders per GP per year/ per total patient contacts per year in block A and B.
- TimepointsN/A
- Trial web siteN/A
- statusinclusion stopped: follow-up
- CONTACT FOR PUBLIC QUERIESDrs. Jody Martens
- CONTACT for SCIENTIFIC QUERIESProf. Dr. H. Severens
- Sponsor/Initiator University Maastricht (UM), CAPHRI Research Institute
- Funding
(Source(s) of Monetary or Material Support)
VGZ, Central Sickfund (CZ) health care insurance
- PublicationsN/A
- Brief summaryIt is difficult to keep control over prescribing behaviour in general practices, despite the development and distribution of guidelines.
The purpose of this study is to assess the initial effects of reactive computer reminders on drug prescribing behaviour.
We executed a clustered RCT with an incomplete block design. The intervention group was randomly allocated into two groups in the south of the Netherlands: 25 GPs received reminders on antibiotics and asthma/COPD prescriptions, 28 GPs received reminders on cholesterol prescriptions.
Prescription guidelines were integrated into a GP computer program, which was installed in the GPs practices in the intervention group. Based on this computer program, a reminder popped up if the GP did not follow the prescribing advices of the guidelines. The guidelines contained recommendations on antibiotics, asthma/COPD drugs and cholesterol drugs.
The main outcome measures were expressed as prescribing performance indicators.
- Main changes (audit trail)
- RECORD8-sep-2005 - 2-sep-2009


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