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Coupling between brain and muscles in response to mechanical perturbations.


- candidate number8969
- NTR NumberNTR2701
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR19-jan-2011
- Secondary IDs34673 ABR
- Public TitleCoupling between brain and muscles in response to mechanical perturbations.
- Scientific TitleCorticomuscular coupling in response to mechanical perturbations.
- ACRONYM
- hypothesisThe control of voluntary movement involves different parts of the central nervous system. The involvement of the cortex in the control of movement is not always incorporated in research on motor control. In this study we will use system identification technique in order to study functional corticomuscular coupling in the time and frequency domain.
- Healt Condition(s) or Problem(s) studiedMovement disorders
- Inclusion criteria1. Age between 18 and 50 years old;
2. Written informed consent.
- Exclusion criteria1. Injury of the dominant wrist in the past year;
2. Suffer from any movement disorder;
3. Suffer from a sever medical condition.
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupParallel
- TypeSingle arm
- Studytypeintervention
- planned startdate 15-mrt-2011
- planned closingdate30-apr-2011
- Target number of participants20
- InterventionsPosition perturbations while the subject applies a constant force against a manipulandum.
- Primary outcomeCorticomuscular coherence and impulse response functions from perturbation to EMG and EEG.
- Secondary outcomeN/A
- TimepointsDuring one session of approximately 2,5 hours, EEG and EMG are recorded during motor tasks. During the motor task the subject is perturbed by continuous position perturbations.
- Trial web siteN/A
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIESMSc. S.F. Campfens
- CONTACT for SCIENTIFIC QUERIESMSc. S.F. Campfens
- Sponsor/Initiator University of Twente
- Funding
(Source(s) of Monetary or Material Support)
MIRA institute, University of Twente
- PublicationsN/A
- Brief summaryObjective:
Study cortical involvement in motor control using system identification techniques in the time and frequency domain.

Method:
Electrophysiological signals will be recorded from the subjectís scalp and over three muscles in the lower arm while the subject exerts a constant force to a manipulandum. The manipulandum will apply perturbations in the form of wrist angle changes. Using different perturbations we will look at coupling measures in the time domain (proprioceptive evoked potentials) end the frequency domain (corticomuscular coherence).

Countries of recruitment:
The Netherlands.
- Main changes (audit trail)
- RECORD19-jan-2011 - 15-jan-2012


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