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Effect of thoracic epidural anesthesia (TEA) on right ventricular function and ventricular-pulmonary coupling.


- candidate number9285
- NTR NumberNTR2844
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR29-mrt-2011
- Secondary IDsP10.225 METC LUMC
- Public TitleEffect of thoracic epidural anesthesia (TEA) on right ventricular function and ventricular-pulmonary coupling.
- Scientific TitleEffect of thoracic epidural anesthesia (TEA) on right ventricular function and ventricular-pulmonary coupling.
- ACRONYM
- hypothesisN/A
- Healt Condition(s) or Problem(s) studiedThoracic epidural anesthesia (TEA), Right ventricular function, Ventricular pulmonary coupling
- Inclusion criteriaPatients undergoing lungresection.
- Exclusion criteriaContra indication epidural anesthesia.
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupParallel
- TypeSingle arm
- Studytypeintervention
- planned startdate 1-mei-2011
- planned closingdate1-mei-2012
- Target number of participants10
- InterventionsRight ventricular function will be assessed by invasive pressure-volume loop analysis using combined pressure-conductance catheters. The response of right ventricular function to increased afterload, induced by brief, partial clamping of the pulmonary artery, will be tested before and after induction of TEA.
- Primary outcomePressure–volume signals acquired during steady state yield end-diastolic and end-systolic volume (EDV, ESV), ejection fraction (EF), end-diastolic and end-systolic pressure (EDP, ESP), stroke work (SW), dP/dtMAX and dP/dtMIN, and isovolumic relaxation time constant Tau. The end-systolic pressure–volume relation (ESPVR: ESP vs. ESV) and the preload recruitable stroke work relation (PRSWR: SW vs. EDV) quantify systolic ventricular function. The slope of the ESPVR determines end-systolic elastance Ees. The end-diastolic pressure-volume relation (EDPVR: EDP vs. EDV) is used to determine diastolic function, quantified by diastolic chamber stiffness and the stiffness constant. Right ventricular afterload is determined by effective arterial elastance Ea, calculated as ESP/SV. Ventricular-arterial coupling is quantified as Ees/Ea.
- Secondary outcomeECG, Heart rate (beats/min), NIBP (mmHg), SpO2 (%), Systolic Blood Pressure (mmHg), Diastolic Blood Pressure (mmHg), Mean Arterial Pressure (mmHg), Cardiac Output (l/min).
- TimepointsBefore and after Thoracic epidural anesthesia.
- Trial web siteN/A
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIESDrs. J. Wink
- CONTACT for SCIENTIFIC QUERIESDrs. J. Wink
- Sponsor/Initiator Leiden University Medical Center (LUMC), Department of Anaesthesiology
- Funding
(Source(s) of Monetary or Material Support)
Leiden University Medical Center (LUMC), Department of Anaesthesiology
- PublicationsN/A
- Brief summaryN/A
- Main changes (audit trail)
- RECORD29-mrt-2011 - 3-apr-2015


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