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Oxytocin and empathic behavior.


- candidate number9312
- NTR NumberNTR2853
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR7-apr-2011
- Secondary IDsNL36378.058.11 CCMO
- Public TitleOxytocin and empathic behavior.
- Scientific TitleOxytocin and implicit empathic behavior.
- ACRONYM
- hypothesisOxytocin administration leads to stronger empathic reponses and faster emotional processing.
- Healt Condition(s) or Problem(s) studiedEmpathy, Emotional processing
- Inclusion criteria1. Male;
2. Age 18 - 35;
3. Healthy (see exclusion criteria).
- Exclusion criteria1. Major physical illness such as heart problems, high blood pressure, diabetis, epilepsy, liver disease, or any other serious medical condition;
2. Current or past (< 5 years) psychiatric disorders, as assessed by selfreport;
3. Medication use that can interfere with the study;
4. Use of more than 3 glasses of alcohol per day;
5. Use of more than 10 cigarettes per day;
6. Use of hard drugs;
7. Common use of soft drugs (cannabis) - at least once per week in the last 3 months.
- mec approval receivedno
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlPlacebo
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-jul-2011
- planned closingdate1-dec-2011
- Target number of participants20
- InterventionsA nasal oxytocin spray is administered once containing 24 IU oxytocin (6 puffs). This will be compared with a placebo nasal spray in a cross-over design. Thirty minutes after nasal spray administration computer tasks will be performed to measure the effects of the oxytocin spray versus placebo.
- Primary outcome1. Electromyographic (EMG) responses to presented happy and angry faces;
2. Attentional bias to happy and anxious faces over neutral faces;
3. The amount of distraction by emotional pictures compared to neutral pictures during a working memory task.
- Secondary outcomeThe effect of oxytocin administration will be compared between subjects that score high or low on questionnaires measuring, anxiety, depression, empathy and autistic traits.
- TimepointsPlacebo controlled cross-over design with 1 week in between. Tasks will be performed within 90 minutes after nasal spray administration.
- Trial web siteN/A
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIES Marieke S. Tollenaar
- CONTACT for SCIENTIFIC QUERIES Marieke S. Tollenaar
- Sponsor/Initiator Leiden University Medical Center (LUMC)
- Funding
(Source(s) of Monetary or Material Support)
Leiden University, Department of Clinical Psychology
- PublicationsN/A
- Brief summaryEmpathy is a human emotion related to understanding and feeling the emotions of others. Lately, there has been increasing interest in the neurobiological backgrounds of empathy. The hormone oxytocin (OT) seems to play an important role in empathy and in empathy related disorders. In this study we will investigate the effects of 24 IU intranasal oxytocin administration on implicit empathic behaviors in healthy male volunteers. We will measure automatic facial mimicry to, and attentional bias for emotional faces, and the strength of distraction by emotional information both after oxytocin and after a placebo spray in a double-blind crossover design. We expect OT to increase empathic responding.
- Main changes (audit trail)
- RECORD7-apr-2011 - 8-sep-2012


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