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Effects of weight loss on stimulated lipolysis.


- candidate number10230
- NTR NumberNTR3019
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR10-aug-2011
- Secondary IDs11-3-019 METC
- Public TitleEffects of weight loss on stimulated lipolysis.
- Scientific TitleEffects of weight loss on adipose tissue β2-AR-stimulated lipolysis: Role of adipose tissue oxidative stress and hypoxia.
- ACRONYMBeta2LIPWL
- hypothesisModerate weight loss increases sensitivity to β2-AR-stimulated lipolysis in isolated adipocytes from subcutaneous adipose tissue biopsies.
- Healt Condition(s) or Problem(s) studiedObesity, Lipolysis, Beta2-adrenergic sensitivity
- Inclusion criteria1. All subjects entering the Co-Eur programme;
2. Age > 18 years old;
3. No more than 3 kg weight change in the past 3 months.
- Exclusion criteria1. Smoking;
2. Diabetes;
3. (Medicinal) use of β-blockers or β-agonists;
4. Pregnant women;
5. Blood clotting problems or (medicinal) use of anticoagulantia.
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupParallel
- TypeSingle arm
- Studytypeintervention
- planned startdate 1-jul-2011
- planned closingdate1-jan-2013
- Target number of participants37
- InterventionsSubjects follow the standard weight loss programme in Heerlen (NL) provided by CO-EUR without interference by the researchers.
CO-EUR is an obesity treatment centre which uses an 18-month-lasting programme with a multi-disciplinary approach, including diet, physical activity and behaviour change, to treat people with obesity.
- Primary outcomeChanges in sensitivity to β2-AR-stimulated lipolysis in adipocytes isolated from subcutaneous adipose tissue biopsies.
- Secondary outcome1. Changes in markers of adipose tissue hypoxia;
2. Changes in markers of adipose tissue and systemic oxidative stress.
- Timepoints1. Premeasurements will be done before the start of the CO-EUR programme;
2. Postmeasurements will be done after 9 months of participation in the CO-EUR programme. Postmeasurements will be done in every subject, who is still participating in the Co-Eur programme after 9 months, regardless of the amount of weight lost or gained in those 9 months.
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIESDrs. K.F.M. Teunissen-Beekman
- CONTACT for SCIENTIFIC QUERIESProf. Dr. M.A. Baak, van
- Sponsor/Initiator University Maastricht (UM)
- Funding
(Source(s) of Monetary or Material Support)
University Maastricht (UM)
- PublicationsN/A
- Brief summaryThis study investigates the effects of weight loss on beta2-adrenergic stimulated lipolysis in isolated adipocytes. In addition the effects of weight loss on adipose tissue hypoxia and adipose tissue and systemic oxidative stress will be determined.
- Main changes (audit trail)
- RECORD10-aug-2011 - 4-sep-2011


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