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Interval colorectal cancer in a Dutch population: Epidemiological, clinical and pathological characteristics and molecular analysis.


- candidate number10414
- NTR NumberNTR3093
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR6-okt-2011
- Secondary IDs10-4-061.4/pl / 11-N-79; METC MUMC / METC Atrium MC Heerlen
- Public TitleInterval colorectal cancer in a Dutch population: Epidemiological, clinical and pathological characteristics and molecular analysis.
- Scientific TitleInterval colorectal cancer in a Dutch population: Epidemiological, clinical and pathological characteristics and molecular analysis.
- ACRONYM
- hypothesisWhat are the causes of interval colorectal cancers? Are they the result of technology related or biology related factors?
1. Interval colorectal cancers (CRCs) are more common than expected;
2. Interval CRCs are characterized by a different macroscopic appearance, rendering them more likely to be missed in routine colonoscopy;
3. Precursor lesions of interval CRCs have different molecular features which are associated with an increased risk for rapid progression to CRC.
- Healt Condition(s) or Problem(s) studiedColorectal cancer, Polyps, Adenomas, Colonoscopy, Incidence, Interval colorectal cancer
- Inclusion criteriaAll patients diagnosed with colorectal cancer between January 2001 and December 2010 in the South of Limburg: Maastricht University Medical Center, Atrium Medical Center Heerlen, Orbis Medical Center Sittard.
- Exclusion criteriaPatients with inflammatory bowel disease or known hereditary polyposis syndromes.
- mec approval receivedyes
- multicenter trialyes
- randomisedno
- groupParallel
- TypeSingle arm
- Studytypeobservational
- planned startdate 10-okt-2011
- planned closingdate1-sep-2013
- Target number of participants4000
- InterventionsNone: "niet WMO-plichtig onderzoek".

Retrospective analysis of clinical and pathology records, and molecular analysis on resection specimen.
- Primary outcome1. Prevalence of interval CRCs in a Dutch population;
2. Clinical characteristics;
3. Molecular characteristics;
4. Differences with non-interval CRCs.
- Secondary outcomeN/A
- TimepointsN/A
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESDrs. C. Clercq, le
- CONTACT for SCIENTIFIC QUERIESDr. S. Sanduleanu
- Sponsor/Initiator
- Funding
(Source(s) of Monetary or Material Support)
- PublicationsN/A
- Brief summaryIn routine practice, interval colorectal cancers (cancers that develop after a colonoscopy) are more common than previously expected. Variations between endoscopists with regard to detection and effective treatment of precursor lesions, as well as differences in biology are critical factors, yet their precise contribution remains unclear. In view of the forthcoming screening for colorectal cancers (CRCs) in the Netherlands, this issue is timely as it may permit to design more effective CRC preventive strategies and provide new insights into the pathogenesis of CRC.
- Main changes (audit trail)
- RECORD6-okt-2011 - 21-okt-2011


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