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Studie naar TRPV1 expressie in mononucleaire cellen uit perifeer bloed van cystinose patiŽnten.


- candidate number10590
- NTR NumberNTR3166
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR29-nov-2011
- Secondary IDsS53728 Clinical Trial Center UZ Leuven, BelgiŽ
- Public TitleStudie naar TRPV1 expressie in mononucleaire cellen uit perifeer bloed van cystinose patiŽnten.
- Scientific TitleStudy of TRPV1 expression in peripheral blood mononuclear cells of cystinosis patients.
- ACRONYM
- hypothesisThe first two exons of TRPV1 are deleted in the most common mutation found in cystinosis patients: A large 57 kb deletion. We aim to study TRPV1 expression in cystinosis patients both homozygous and heterozygous for this deletion.
- Healt Condition(s) or Problem(s) studiedTRPV1, Cystinosis
- Inclusion criteriaAll cystinosis patients that are in follow-up in the University Hospitals Leuven, Belgium.
- Exclusion criteriaPatients refusing their cooperation to the study.
- mec approval receivedno
- multicenter trialno
- randomisedno
- groupParallel
- TypeSingle arm
- Studytypeobservational
- planned startdate 28-nov-2011
- planned closingdate31-dec-2012
- Target number of participants10
- InterventionsBlood withdrawal.
Peripheral blood mononuclear cells (PBMC) will be isolated from whole blood using a Ficoll gradient centrifugation. Next, RNA will be isolated from these PBMC. TRPV1 expression will be measured by qPCR in the PBMC RNA.
- Primary outcomeTRPV1 exression.
- Secondary outcomeN/A
- TimepointsN/A
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIES Martine Besouw
- CONTACT for SCIENTIFIC QUERIES Martine Besouw
- Sponsor/Initiator University Hospitals Leuven
- Funding
(Source(s) of Monetary or Material Support)
University Hospitals Leuven
- PublicationsN/A
- Brief summaryThe first two exons of TRPV1 are deleted in the most common mutation found in cystinosis patients: a large 57 kb deletion. We aim to study TRPV1 expression in cystinosis patients both homozygous and heterozygous for this deletion.
- Main changes (audit trail)
- RECORD29-nov-2011 - 12-dec-2011


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