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Prism adaptation as a two-week treatment.


- candidate number11085
- NTR NumberNTR3278
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR4-feb-2012
- Secondary IDs 
- Public TitlePrism adaptation as a two-week treatment.
- Scientific TitlePrism adaptation as a two-week treatment.
- ACRONYMPAiR
- hypothesisThe current study will focus on the effects of an intensive programme of exposure to prism adaptation (i.e. daily exposure during two weeks) and whether more permanent changes in spatial awareness can be objectified. To assess the effects of prism adaptation in the proposed study, patients will receive either prism adaptation or sham adaptation. We expect longer-lasting, more general beneficial effects after prism adaptation compared to sham adaptation.
- Healt Condition(s) or Problem(s) studiedHemispatial neglect
- Inclusion criteria1. Patients with hemispatial neglect;
2. 18-85 years of age;
3. No history of psychiatric disorders and/or substance abuse.
- Exclusion criteria1. < 18 years of age, >85 years of age;
2. History of psychiatric disorders and/or substance abuse;
3. Unable to perform neuropsychological screening and/or tests.
- mec approval receivedno
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlPlacebo
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-jan-2013
- planned closingdate1-jan-2015
- Target number of participants60
- InterventionsThe prism adaptation procedure will be similar to that employed by Rossetti et al (1998), with the exception that it will be repeated on a daily basis for 2 weeks. Prism adaptation will be performed with a pair of goggles fitted with wide-field point-to-point prismatic lenses, inducing a rightward optical shift of 10.

Sham adaptation will be performed with a pair of goggles fitted with plain lenses (i.e. no optical shift).
- Primary outcome1. Star cancellation;
2. Letter cancellation;
3. Line bisection;
4. Landmark test;
5. Copying;
6. Symmetrical photos;
7. Mental representations.
- Secondary outcome1. Balance board;
2. Mobility Assessment Course;
3. Postural Assessment Scale for Stroke Patients;
4. Subjective Neglect Questionnaire;
5. Catherine Bergego Scale.
- Timepoints1. Baseline (T0);
2. After 1 week of PA (T1);
3. After 2 weeks of PA (T2);
4. 1 week after ending PA (T3);
5. 2 weeks after ending PA (T4);
6. 4 weeks after ending PA (T5);
7. 12 weeks after ending PA (T6).
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIESDr. Tanja C.W. Nijboer
- CONTACT for SCIENTIFIC QUERIESDr. Tanja C.W. Nijboer
- Sponsor/Initiator Revalidatiecentrum De Hoogstraat
- Funding
(Source(s) of Monetary or Material Support)
NWO
- PublicationsN/A
- Brief summaryUnilateral spatial neglect occurs frequently following a brain lesion in especially the right hemisphere (25-30% of all stroke patients, Appleros et al, 2002), resulting in a failure to report or respond to stimulation in contralesional hemispace. Prism adaptation is the most widely studied method to alleviate the symptoms of neglect. Effects of a single session of prism adaptation have been reported across clinical measures, but also in more daily situations, such as wheelchair navigation (Rossetti et al, 1999) and postural control (Tilikete et al, 2001). The current study will focus on the effects of an intensive programme of exposure to prism adaptation (i.e. daily exposure during two weeks) and whether more permanent changes in spatial awareness can be objectified. To assess the effects of prism adaptation in the proposed study, patients will receive either prism adaptation or sham adaptation. We expect longer-lasting, more general beneficial effects after prism adaptation compared to sham adaptation.
- Main changes (audit trail)
- RECORD4-feb-2012 - 25-feb-2012


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