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van CCT (UK)

van CCT (UK)

Imaging mental imagery in Anorexia Nervosa.

- candidate number13120
- NTR NumberNTR3517
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR10-jul-2012
- Secondary IDs11-540 METC
- Public TitleImaging mental imagery in Anorexia Nervosa.
- Scientific TitleImaging mental imagery in Anorexia Nervosa.
- hypothesisRelative to the control condition of 'recall only' the experimental condition of 'recall + eye movements' will produce a reduction in both the 1) subjective vividness/emotionality of the mental image and associated recall-induced increases in heart rate, and the 2) brain responses in areas responding to the emotional content of memories. In addition, we expect that 3) effects 1 and 2 will be negatively correlated with executive functioning.
- Healt Condition(s) or Problem(s) studiedAnorexia
- Inclusion criteria1. Right-handed;
2. Female;
3. Age between 18 and 35 years of age at the day of screening;
4. Diagnosed with AN or ED-NOS (as defined by the DSM IV criteria);
5. A BMI below 17.5 kg/m2.
- Exclusion criteria1. Having a history of or current excessive alcohol consumption (> 28 units per week);
2. Having a drug dependency;
3. Smoking daily;
4. Contra-indications to MRI scanning on the basis of the MRI screening form, including:
A. Claustrophobia;
B. Metal objects in the body incompatible with MRI scanning;
C. Having a history of medical or surgical events that may significantly affect the study outcome, such as brain surgery.
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupParallel
- Type2 or more arms, randomized
- Studytypeobservational
- planned startdate 4-jul-2012
- planned closingdate31-okt-2012
- Target number of participants20
- InterventionsN/A
- Primary outcome1. Emotionality and vividness ratings;
2. Neural activation (BOLD signal change) in response to memory recall.
- Secondary outcomeCognitive functioning (working memory capacity as measured with the n-back test, set shifting as measured with the WSCT, central coherence as measured with the RCFT and decision making as measured with the IGT).
- TimepointsThe study consists of 1 session with 2 runs.
- Trial web siteN/A
- statusopen: patient inclusion
- Sponsor/Initiator Utrecht University (UU)
- Funding
(Source(s) of Monetary or Material Support)
Utrecht University (UU)
- PublicationsN/A
- Brief summaryIn Anorexia Nervosa (AN), aversive images about past or anticipated future pathology-related events are essential to the maintenance of the disorder and relapse after treatment. An effective intervention to reduce the vividness and emotionality of these aversive memories is to tax working memory during negative image recall, previously shown in anxiety disorders. Taxing working memory may also be an effective intervention for intrusive AN-related memories, considering the crucial role of mental imagery in AN. The aim of this study is to therapeutically target upsetting intrusions experienced by AN patients. We hypothesize that taxing working memory reduces emotionality of upsetting imagery and that brain responses during retrieval of these images are diminished.
In this experimental study interventions were derived from the Eye Movement and Desensitisation Reprocessing (EMDR) technique, of which taxing working memory during recall has been identified as the critical factor. 20 AN patients will participate in a functional MRI scan session with four runs, during which negative memories will be retrieved before and after recall sessions, with or without simultaneous eye movements. Reduction in emotionality of upsetting imagery (after taxing working memory and recall only) will be measured by subjective responses and heart rate, reduction in brain responses will be measured with functional MRI.
- Main changes (audit trail)
- RECORD10-jul-2012 - 11-aug-2012

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