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Rotation of antihypertensive drugs in ethnic groups.


- candidate number1610
- NTR NumberNTR384
- ISRCTNISRCTN08931855
- Date ISRCTN created19-dec-2005
- date ISRCTN requested28-okt-2005
- Date Registered NTR13-sep-2005
- Secondary IDsN/A 
- Public TitleRotation of antihypertensive drugs in ethnic groups.
- Scientific TitleRotation of antihypertensive drugs in ethnic groups.
- ACRONYMROTATIE
- hypothesisInterindividual variation in antihypertensive drug response can be predicted through lifestyle, demographics and plasma drug levels.
- Healt Condition(s) or Problem(s) studiedHypertension
- Inclusion criteriaSubjects with uncomplicated hypertension between the ages of 36 and 60 years.
- Exclusion criteriaSerious hypertensive organ damage co-morbidity.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlActive
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-jan-2001
- planned closingdate31-dec-2004
- Target number of participants102
- Interventions6 week periods of antihypertensive drug treatment in monotherapy with 3 weeks washout. Drugs: A lisinopril B nebivolol C barnidipine D HCl thiazide E eprosartan.
- Primary outcome1. Office blood pressure measured with an automatic device;
2. Side effects measured with a questionnaire.
- Secondary outcomeN/A
- TimepointsN/A
- Trial web siteN/A
- statusinclusion stopped: follow-up
- CONTACT FOR PUBLIC QUERIESDr. R.P. Koopmans
- CONTACT for SCIENTIFIC QUERIESDr. G.A. Montfrans, van
- Sponsor/Initiator Academic Medical Center (AMC, Amsterdam)
- Funding
(Source(s) of Monetary or Material Support)
Menarini farma Benelux, Yamanouchi Benelux, Solvay Benelux
- PublicationsN/A
- Brief summaryThe choice of antihypertensive drugs for individual patients is difficult. We try to make a predictive model depending on class effects of the 5 amin anti-hypertensive drug classes that can later be tested prospectively. The etnic groups in teh trial have been explicitely defined in advance.
- Main changes (audit trail)
- RECORD13-sep-2005 - 23-jun-2008


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