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Nocturnal muscle protein synthesis after neuromuscular electrical stimulation in elderly men.


- candidate number14727
- NTR NumberNTR3952
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR15-apr-2013
- Secondary IDs44582 / 13-3-024; ABR / METC MUMC
- Public TitleNocturnal muscle protein synthesis after neuromuscular electrical stimulation in elderly men.
- Scientific TitleNocturnal muscle protein synthesis after neuromuscular electrical stimulation in elderly men.
- ACRONYMES-PROvernight
- hypothesisIs overnight incorporation of [1-13C]-phenylalanine amino acids higher in muscle tissue in combination with NMES than in unstimulated skeletal muscle?
- Healt Condition(s) or Problem(s) studiedSarcopenia, Muscle mass, Protein, Neuromuscular electrostimulation
- Inclusion criteria1. Written informed consent;
2. Age ≥ 65 years;
3. Male.
- Exclusion criteria1. Type II diabetes;
2. All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders, paralysis, hip/knee surgery);
3. Use of anticoagulants, blood diseases, allergy for lidocain;
4. Use of NSAIDs and acetylsalicylic acid;
5. Patients suffering from PKU (Phenylketonuria);
6. Presence of implantable cardioverter defibrillator and/or pacemaker;
7. Performed regular resistance type exercise in the past 6 months;
8. Use of any tools to assist during walking (cane/ crutches/ walker);
9. (Partial) foot/ leg amputation.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingSingle
- controlNot applicable
- groupParallel
- TypeSingle arm
- Studytypeintervention
- planned startdate 1-mei-2013
- planned closingdate1-jan-2014
- Target number of participants12
- InterventionsConsumption of a 40 g bolus of intrinsically L[1-13C]-phenylalanine labeled casein protein and 70 min of one-legged NMES.
- Primary outcomePrimary parameter of this study will be overnight incorporation of stable isotope amino acids from the intrinsically labeled drink.
- Secondary outcomeSecondary parameter of this study will be plasma amino acid enrichment after ingestion of the intrinsically labeled protein.
- TimepointsOvernight (i.e. the morning after ingestion of the stable isotope drink and NMES). Method of measurement is massaspectrometry.
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIESBa. B. Groen
- CONTACT for SCIENTIFIC QUERIESDr. L.J.C. Loon, van
- Sponsor/Initiator University Maastricht (UM), Department Movement Science
- Funding
(Source(s) of Monetary or Material Support)
University Maastricht (UM)
- PublicationsN/A
- Brief summaryRationale:
With human aging there is a gradual but progressive decline in skeletal muscle mass, termed sarcopenia. While the underlying cause of sarcopenia is likely to be multifaceted, a primary factor is that elderly individuals frequently experience short periods of muscle disuse following limb immobilization or bed-rest (due to injury or illness) causing rapid muscle loss. Feasible strategies for maintaining muscle protein synthesis rates in elderly individuals, and thus having the potential to attenuate the loss of muscle mass during disuse need to be pursued. Local neuromuscular electrical stimulation (NMES) in combination with additional intake of protein offer such a potential strategy but, as yet, remains relatively unexplored.

Objective:
To test the hypothesis that ingesting a nocturnal bolus of protein in combination with NMES stimulates muscle protein synthesis in elderly more than ingesting protein without NMES.

Study design:
Prospective, single blind, intervention study.

Intervention:
Consumption of a 40 g bolus of intrinsically L[1-13C]-phenylalanine labeled casein protein and 70 min of one-legged NMES.

Endpoints:
Enrichments of muscle tissue after ingestion of an [1-13C]-phenylalanine intrinsically labeled casein drink.
- Main changes (audit trail)
- RECORD15-apr-2013 - 2-sep-2013


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