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Testosterone, aging and cognitive functioning.


- candidate number1218
- NTR NumberNTR404
- ISRCTNISRCTN42645787
- Date ISRCTN created28-feb-2007
- date ISRCTN requested18-nov-2005
- Date Registered NTR13-sep-2005
- Secondary IDsA300413 
- Public TitleTestosterone, aging and cognitive functioning.
- Scientific TitleTestosterone, aging and cognitive functioning.
- ACRONYMOLDER
- hypothesisSerum testosterone levels in men will be related to basic cognitive functions, such as mental processing speed and cognitive control.
- Healt Condition(s) or Problem(s) studiedBenign prostatic hyperplasia (BPH), Fertility problems
- Inclusion criteria1. Age between 55 and 75 or age between 20 and 45;
2. Urological complaints suspected to be BPH or fertility symptoms;
3. Subjective healthy impression.
- Exclusion criteriaN/A
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeintervention
- planned startdate 21-mrt-2005
- planned closingdate1-mrt-2007
- Target number of participants200
- InterventionsComputer tests.
- Primary outcomeWe expect a correlation between serum level testosterone and basic cognitive functions such as cognitive speed and cognitive control.
- Secondary outcomeThe relative contributions of age and testosterone level to cognitive functions will be established.
- TimepointsN/A
- Trial web siteN/A
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIESDr. J.W. Strien, van
- CONTACT for SCIENTIFIC QUERIESProf. Dr. C.H. Bangma
- Sponsor/Initiator Erasmus Medical Center, Department of Urology
- Funding
(Source(s) of Monetary or Material Support)
Erasmus Medical Center, Department of Urology
- PublicationsN/A
- Brief summaryRecent research showed a correlation between age related changes in hormone levels and cognitive decline and the emergence of Alzheimer disease in both men and women.
Most research however is conducted in women.
The aim of this study is to further investigate the relation between testosterone level and cognitive functioning in older men. In order to determine testosterone level, total-, SHBG- and albumin bound and bioavailable testosterone will be measured.
Three cognitive computer tests are aimed to measure basal information processing speed, ability to suppress irrelevant stimuli and visuospatial perception, respectively.
Two out-patient groups will be included:
1. BPH-patients in the age of 55-75, and
2. patients with fertility symptoms in the age of 20-45 years.
- Main changes (audit trail)
- RECORD16-aug-2005 - 16-nov-2009


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