Who are we?


Signup for

Online registration

Log in to register
your trial

Search a trial




van CCT (UK)

van CCT (UK)

Neuropsychological functioning of COPD patients

- candidate number15584
- NTR NumberNTR4215
- ISRCTNISRCTN wordt niet meer aangeleverd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR21-okt-2013
- Secondary IDsNL45127.068.13 METC 13-3-035
- Public TitleNeuropsychological functioning of COPD patients
- Scientific TitleNeuropsychological functioning of COPD patients and the influence on health status, daily functioning and the outcome of pulmonary rehabilitation
- hypothesisPatients with COPD have worse cognitive functioning compared to healthy controls. This may influence health status, daily functioning and the outcome of pulmonary rehabilitation in these patients.
- Healt Condition(s) or Problem(s) studiedChronic Obstructive Pulmonary Disease (COPD)
- Inclusion criteriaPatients:
* Diagnosis: COPD according to the GOLD definition.

Matched control group:
* Partner, brother or sister of an included patient.
* Smoking status comparable with smoking status from included patient.
- Exclusion criteriaPatients:
* Patient is not clinically stable during 4 weeks preceding enrolment.
* Previous diagnosis of dementia.
* Patient does not speak Dutch well enough to participate.

Brain MRI patient group:
* The patient has a pacemaker, cochlear implant, neurostimulator or other electronic implants, surgery with metal implants, or ever had a metal splinter in the eye.
* The patient suffers from claustrophobia.

Matched control group:
* Diagnoses of COPD or Asthma.
* Previous diagnosis of dementia.
* Participant does not speak Dutch well enough to participate.
* Age of the matched control differ more than 10 years from the age of the patient for who he/she was matched.
* Level of education of the matched control differs more than 1 level from the level of education for who he/she was matched (according to the scoring system of the CBS).
- mec approval receivedyes
- multicenter trialyes
- randomisedno
- groupParallel
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-nov-2013
- planned closingdate1-dec-2016
- Target number of participants283
- Interventionsn/a
- Primary outcomeNeuropsychological functioning.
- Secondary outcomeDemographics, general psychological functioning and other clinical characteristics (e.g. pulmonary function and saturation measure), problematic activities of daily life, patient information needs and brain abnormalities.
- TimepointsBefore and after an 8-14 week pulmonary rehabilitation program.
- Trial web siteN/A
- statusinclusion stopped: follow-up
- Sponsor/Initiator CIRO+ (Centre of expertise for chronic organ failure)
- Funding
(Source(s) of Monetary or Material Support)
The Weijerhorst Foundation, Maastricht, the Netherlands
- Publicationsn/a
- Brief summaryPatients with Chronic Obstructive Pulmonary Disease (COPD) may experience dyspnoea, fatigue and problems in daily functioning, despite optimal pharmacological treatment. It is important that patients follow a number of precepts in order to minimize the consequences of the illness. Before a patient is willing to follow the precepts, a patient needs to experience that the new behaviour yields more advantages, compared to the old behaviour. Patients need specific cognitive abilities in order to make a considered choice. Previous research suggests that the cognitive functions of COPD patients may be impaired. However, results of previous research are disputable. To date, remains unclear which clinical characteristics are related to cognitive functioning in COPD patients and whether and to what extent cognitive functioning is related to daily functioning, health status and the outcome of pulmonary rehabilitation.
- Main changes (audit trail)
- RECORD21-okt-2013 - 27-feb-2016

  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar