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Effect of IVF culture medium on health of IVF children


- candidate number15593
- NTR NumberNTR4220
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR22-okt-2013
- Secondary IDsNL45845.068.13  
- Public TitleEffect of IVF culture medium on health of IVF children
- Scientific TitleEffect of IVF culture medium on health of IVF children
- ACRONYMMEDIUM-KIDS
- hypothesisIVF culture medium affects parameters of metabolic syndrome at childhood stage
- Healt Condition(s) or Problem(s) studiedIVF, Growth, Cardiometabolic health
- Inclusion criteriaIVF group: born after an IVF treatment at the MUMC applied in the period July 2003 December 2006
CONTROL: 9 years old, singleton
- Exclusion criteriaIVF group: Born after preimplantation genetic diagnosis (PGD)
CONTROL1:conceived by any form of assisted reproduction
CONTROL 2:having a disorder that affects lipid profile or glucose metabolism
- mec approval receivedno
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytype[default]
- planned startdate 15-nov-2013
- planned closingdate1-okt-2016
- Target number of participants731
- InterventionsThe children in the IVF group are born after, as an embryo, being cultured in two different commercially available culture media. The two groups will be mutually compared as well as with a control group consisting of children that were conceived naturally.
- Primary outcomeLength, height, skinfold thickness, blood pressure, endothelial function, lipid profile in blood, cortisol level
- Secondary outcomeDNA methylation
- TimepointsAll children will be investigated at the age of 9 years old.
- Trial web sitehttp://www.maastrichtuniversity.nl/web/show/id=6422717/langid=42
- statusplanned
- CONTACT FOR PUBLIC QUERIES A. Montfoort, van
- CONTACT for SCIENTIFIC QUERIES A. Montfoort, van
- Sponsor/Initiator Academic Hospital Maastricht (AZM)
- Funding
(Source(s) of Monetary or Material Support)
March of Dimes
- PublicationsN/A
- Brief summaryFrom animal studies it is known that embryo culture leads to growth, behavioural and cardio-metabolic alterations in the offspring. Embryo culture effects on human offspring have long been uninvestigated, until a few years ago when we found that the medium used to culture embryos in an IVF treatment has a significant effect on the incidence of low birth weight (LBW) and on birth weight. As this was the first randomized trial on embryo culture effects in human, nothing is known about health effects at later stages of development. Since a lower birth weight is related to an increased risk for (adult) chronic diseases belonging to metabolic syndrome (Barker theory), our findings raise concern for the IVF progeny. In advance of diseases at adult age, we hypothesize that IVF culture medium affects parameters of metabolic syndrome at childhood stage.
- Main changes (audit trail)
- RECORD22-okt-2013 - 19-nov-2013


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