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platelets under pressure


- candidate number15513
- NTR NumberNTR4235
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR8-okt-2013
- Secondary IDsMETC 13-4-087 
- Public Titleplatelets under pressure
- Scientific Titlewhat is the influence of pressure, heat and the combiation of both on the function platelets concentrated for the purpose of transfusion.
- ACRONYM
- hypothesispressure, heat and the combination of both do not negatively influence platelet function.
- Healt Condition(s) or Problem(s) studiedPlatelet reactivity, Pressure parameters
- Inclusion criteria10 platelet concentrates with the same age
- Exclusion criteriaconcentrate with different ages
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupCrossover
- TypeSingle arm
- Studytypeintervention
- planned startdate 14-okt-2013
- planned closingdate14-jan-2014
- Target number of participants10
- InterventionsWe mimick the rapid infusion of blood products in urgent situations where red packed cells are warmed and infusied under pressure by applying
1. pressure (150 mmHg)
2. heat (37-39 degree Celsius)
3. combination of both
on platelet concentrates through a mock system.
- Primary outcomeIn vitro platelet function measurement assessed by multiple impedance aggregometrie (MEA-Multiplate Multiple aggregometer Dynabyte Medical Munich, Germany)) and light transmission aggragometrie (LTA-platelet aggregometer PAR-4 Hart Biologicals Ltd Hartlepool, UK)). Both function tests will be performed before and after the test condition (see above).
- Secondary outcomemicroparticle content measured by ELISA (ZYMUPHEN, MP-activity kit, Aniara, Mason, Ohio, USA) pH, glucose and lactate measured in the Chiron rapid lab 850 blood gas analyser (Siemens Healthcare Diagnostics, Breda, the Netherlands)
- Timepointsbefore and after applying of the experimental conditions
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIESDr. M.D. LancÚ
- CONTACT for SCIENTIFIC QUERIESDr. M.D. LancÚ
- Sponsor/Initiator Maastricht University Medical Center (MUMC+)
- Funding
(Source(s) of Monetary or Material Support)
Self Funding
- PublicationsN/A
- Brief summaryIn emergency clincical condition transfusion of blood products is frequently enhanced by applying pressure and warmth or the combination of both to increase the speed of tansfusion. However platelet concentrates are known to be the most fragile blood products which might might be disrupted in function by applying warmth, pressure or the combnination of both. Aim of the study is to investigate the functional status of platelet concentrates before and after applying pressure or warmth (37-39 degree Celsius) or the combination of both. The in vitro function will be assessed by aggregometrie (impedance and light transmission) and by surrogate parameters (microparticles, glucoes, pH and lactate).
- Main changes (audit trail)
- RECORD8-okt-2013 - 19-nov-2013


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