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van CCT (UK)

Brain patterns of anticipatory and consummatory reward

- candidate number15666
- NTR NumberNTR4249
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR5-nov-2013
- Secondary IDs13/17 (METC -WU) NL45977 (ABR)
- Public TitleBrain patterns of anticipatory and consummatory reward
- Scientific TitleBrain patterns of anticipatory and consummatory reward
- hypothesisWe hypothesize (1) that an anticipatory reward will lead to more activation in reward related areas such as the striatum, amygdala, and dopaminergic midbrain compared to a consummatory reward (preceded by an anticipatory reward). Furthermore, we expect the orbitofrontal cortex to be similarly activated for both reward types. In addition we expect that having an anticipation of a consummatory reward (in this case provoked by a label) can change the perception of this consummatory reward when it is received. We assume that expected pleasantness for the beverage coupled to the light label will be lower than for the beverage coupled to the regular label. Therefore, we hypothesize (2) that the receipt of a consummatory reward presented as a regular product will result in more activation in reward related areas such as the striatum and dopaminergic midbrain (e.g. ventral tegmental area and substantia nigra) compared to the receipt of the same product presented as light. Furthermore, based on previous research, we presume that labels bias food evaluation especially in the amygdala (region associated with emotion) thus that dissociable responses can be found in this region (Grabenhorst et al., 2013).
- Healt Condition(s) or Problem(s) studiedTaste development, Anticipatory and consummatory reward, Light products
- Inclusion criteria1. Age: 18-35 years;
2. Being female;
3. BMI: 18.5 – 25.0 kg/m2;
4. Healthy (as judged by the participant);
5. Being right handed;
6. Willing to comply with the study procedures;
7. Willing to be informed about incidental findings of pathology;
8. Having given written informed consent;
9. Successful completion of the training session.
- Exclusion criteria1. Restraint eating (women: score > 2.80)
2. Lack of appetite
3. Having difficulties with swallowing/eating
4. Usage of an energy restricted diet during the last two months
5. Weight loss or weight gain of 5 kg or more during the last two months
6. Stomach or bowel diseases
7. Diabetes, thyroid disease, kidney disease and other endocrine disorders
8. Having a history of neurological disorders
9. Having taste or smell disorders
10. Having schizophrenia or another serious mental illnesses
11. Usage of daily medication other than oral contraceptives, Paracetamol or hay fever tablets
12. Pregnancy during the last 6 months, having the intention to become pregnant or lactating
13. Smoking on average more than one cigarette/cigar a day
14. Being allergic/intolerant for products under study
15. Exclusive consumption of ‘light’ versions of beverages
16. Avoidance of ‘light’ versions of beverages
17. Disliking the beverages under study
18. Working or doing an internship/thesis at the group Sensory science and eating behavior (WUR)
19. Current participation in other nutrition related or medical research
20. Having a history of or current alcohol consumption of on average more than 28 units per week
21. Having a contra-indication to MRI scanning (including, but not limited to):
Pacemakers and defibrillators
Intraorbital or intraocular metallic fragments
Ferromagnetic implants
Presence of non-removable metal objects in the mouth
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlNot applicable
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 12-dec-2013
- planned closingdate1-jul-2014
- Target number of participants26
- InterventionsParticipants are exposured to three different labels, a light label a regular label and a 'neutral' label, and two tastants, a regular beverage and
a neutral control stimulus.
There are three task conditions:
a) presentation of a light label - consumption of a regular beverage
b) presentation of a regular label - consumption of a regular beverage
c) presentation of a ‘neutral’ label - consumption of a neutral control stimulus These three task conditions are randomized and counterbalanced.
- Primary outcomeThe main study parameters/endpoints are (1) the difference in brain activation between an anticipatory reward and a consummatory reward and (2) the difference in brain activation between a consummatory reward labeled as light versus labeled as regular.
- Secondary outcomeThe 1st secondary study parameter/endpoint is the correlation between brain activation in response to exposure to an anticipatory or a consummatory reward and reaction times and errors (push/pull measure). In addition, two groups will be made based on the product choice outcome and anticipatory reward responses and consummatory reward responses are compared between those groups (i.e. there is looked at the group*reward response interaction). The 2nd secondary study parameter/endpoint is the correlation between brain activation in response to exposure to an anticipatory or a consummatory reward and subject characteristics like reward sensitivity, delayed discounting, impulsivity, health attitude, stress, executive functioning and food neophobia.
- Timepoints1. anticipatory and consummatory brain activation measurements are obtained during one fMRI scan.
2. Questionnaires and tasks are filled out in the weeks before the fMRI scan.
- Trial web siteN/A
- statusopen: patient inclusion
- Sponsor/Initiator Wageningen University, Department of Human Nutrition
- Funding
(Source(s) of Monetary or Material Support)
Wageningen University, Division of Human Nutrition
- PublicationsN/A
- Brief summaryFood reward consist of an anticipatory component often related to the presentation of a cue and a consummatory component related to reward receipt. In the current study we intent to investigate the difference in brain patterns associated with anticipatory (visual cue) and consummatory (taste) reward. ‘Off the shelf’ labels of a light and regular beverage will be used as anticipatory reward cues in order to give more inside on the acceptance of light products/labels.
- Main changes (audit trail)22-apr-2014: Planned start-date was 01-nov-2014, planned closing date was 01-jul-2014. - AB
- RECORD5-nov-2013 - 22-apr-2014

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