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Brain responses to food in children and their parents


- candidate number15665
- NTR NumberNTR4255
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR4-nov-2013
- Secondary IDsMETC UMCU 13-200 ABR NL43992.041.13
- Public TitleBrain responses to food in children and their parents
- Scientific TitleNeural correlates of healthy food viewing and food choice in tweens and their parents
- ACRONYM
- hypothesisWe hypothesize that during the viewing of unhealthy vs. healthy food pictures children will show more activity in areas related to food motivation (striatum, OFC, hippocampus). Likewise, we expect subjects with an unhealthy diet to show more activation than subjects with a healthy diet in these areas. In contrast, during food choice we expect an interaction effect of children vs. adults and unhealthy vs. healthy eaters in areas related to inhibition, such as the anterior cingulate gyrus. Unhealthy eating adults are hypothesized to have less inhibitory control than healthy eating adults, and are therefore expected to show more activation in this area to come to the same result. Children however, are expected to show less activation in this area during inhibition, because the function of the area has not been fully developed yet.
- Healt Condition(s) or Problem(s) studiedChildren, Obesity
- Inclusion criteriaHealthy
Children: age 10-13 y
Children: age-corrected BMI between 20 and 25 kg/m2 or 27.5-35 kg/m2
Parents: age 28-48 y
Parents: BMI between 20 and 35 kg/m2
- Exclusion criteriaLeft handed
Presence of metal in the body incompatible with MRI scanning
Smoking
Having a special diet (e.g. to lose weight, medically prescribed diet in the past 6 months, no meat etc.)
Highly restrained eating.
Having a food allergy
Alcoholconsumption > 28 units/week
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeobservational
- planned startdate 1-okt-2013
- planned closingdate1-jul-2014
- Target number of participants64
- InterventionsSince this is an observational study there are no interventions as a part of the study design. The neural correlates of food choice and food viewing will be examined in two groups of children (healthy weight and overweight) and their same-sexed parent.
- Primary outcome1. Neural activation (percentage signal change) in response to viewing pictures healthy and unhealthy foods.
2. Neural activation (percentage signal change) in response to (un)healthy food choice.
- Secondary outcome1. Scores on the liking of the food images and their perceived healthiness
2. Scores on the neuropsychological measures (DDT, WCST, SST and IGT or HDT).
- TimepointsThere are two moments of measurement, 3-7 days a part. On the first moment of contact neuropsychological measurements and questionnaires will be obtained, on the second moment the fMRI scan will be made.
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESDr. Paul A.M. Smeets
- CONTACT for SCIENTIFIC QUERIESDr. Paul A.M. Smeets
- Sponsor/Initiator University Medical Center Utrecht (UMCU)
- Funding
(Source(s) of Monetary or Material Support)
FP7 EU
- PublicationsN/A
- Brief summaryN/A
- Main changes (audit trail)
- RECORD4-nov-2013 - 18-dec-2013


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