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Think different: effectiveness of an online training for children with obsessive-compulsive disorder


- candidate number15743
- NTR NumberNTR4275
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR22-nov-2013
- Secondary IDsMETC: NL44055.018.13 Fonds NutsOhra: 1204-035
- Public TitleThink different: effectiveness of an online training for children with obsessive-compulsive disorder
- Scientific TitleEffectiveness of an online pre-treatment cognitive bias modification training for children with an obsessive-compulsive disorder
- ACRONYMN/A
- hypothesisThe aim of the present study is to improve treatment for children with OCD by adding an online Cognitive Bias Modification-Interpretation (CBM-I) training as a pre-treatment to cognitive behavioural therapy (CBT). CBM-I is compared with a waitlist condition also followed by CBT. The first hypothesis is that CBM-I results in a decrease of obsessive-compulsive complaints compared to the waitlist condition. The second hypothesis is that CBM-I has a favourable effect (compared to the waitlist condition) on subsequent CBT.
- Healt Condition(s) or Problem(s) studiedObsessive-compulsive disorder (OCD)
- Inclusion criteria- Age: 8-18 jaar
- Primary diagnosis: obsessive-compulsive disorder
- CY-BOCS score >=16
- IQ >=80
- medication (SSRI): stable
- Exclusion criteria- Recent state-of-the-art cognitive behavioral therapy for OCS (within 3 months)
- Psychosis
- Drugs- or alcohol abuse
- mec approval receivedyes
- multicenter trialyes
- randomisedyes
- masking/blindingNone
- controlNot applicable
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 16-okt-2013
- planned closingdate30-apr-2016
- Target number of participants75
- InterventionsA Cognitive Bias Modification – Interpretation (CBM-I) training (12 sessions in 4 weeks) is compared with a waitlist control condition (4 weeks without treatment). The CBM-I procedure (Mathews & Mackintosh, 2000) is adapted for children with OCD. After the CBM-I training / waitlist period, all participants receive cognitive behavioural treatment (16 weekly sessions, protocol ‘Bedwing je dwang’/‘Control your OCD’, De Haan & Wolters, 2009).
- Primary outcomeOCD severity, measured with the Children Yale–Brown Obsessive Compulsive Scale (CY-BOCS; Scahill et al., 1997)
- Secondary outcome- Interpretation bias, measured with a recognition task (Eysenck, Mogg, May, Richards, & Mathews, 1991; Salemink & van den Hout, 2010) and the Obsessive Belief Questionnaire – Child version (OBQ-CV; Coles et al., 2010; Wolters et al., 2011)
- Comorbid problems:
o Child Behavior Checklist (CBCL; Achenbach & Rescorla, 2001; Verhulst & Van der Ende, 1997)
o Youth Self Report (YSR; Achenbach & Rescorla, 2001; Verhulst & Van der Ende, 1997)
o Children’s Depression Inventory (CDI; Timbremont & Braet, 2004)
- General functioning: CGAS score (DSM-IV)
- TimepointsAssessment T0: pre-CBM / pre-waitlist (week 0) - OCD severity (CY-BOCS) - Interpretation bias (OBQ-CV; recognition task) - Comorbidity (CBCL, YSR, CDI) - General functioning (CGAS) Assessment T1: post-CBM / post-waitlist & start CBT (week 4)
- OCD severity (CY-BOCS)
- Interpretation bias (OBQ-CV; recognition task)
- OCD severity (CY-BOCS)
- Interpretation bias (OBQ-CV; recognition task)
- Comorbidity (CBCL, YSR, CDI)
- General functioning (CGAS)
Assessment T2: CBT, 4th session (week 8) - OCD severity (CY-BOCS) Assessment T3: CBT, 8th session (week 12) - OCD severity (CY-BOCS)

Assessment T4: CBT, 12th session (week 16) - OCD severity (CY-BOCS) Assessment T5: post-CBT, 16th session (week 20) - OCD severity (CY-BOCS) - Comorbidity (CBCL, YSR, CDI) - General functioning (CGAS)
- Trial web siteN/A
- statusinclusion stopped: follow-up
- CONTACT FOR PUBLIC QUERIES L.H. Wolters
- CONTACT for SCIENTIFIC QUERIES L.H. Wolters
- Sponsor/Initiator Academic Medical Center (AMC), Amsterdam
- Funding
(Source(s) of Monetary or Material Support)
Fonds Nuts-Ohra, Academic Medical Center (AMC)
- PublicationsN/A
- Brief summaryThe aim of the present study is to improve treatment for children with OCD by adding an online Cognitive Bias Modification–Interpretation (CBM-I) training to cognitive behavioural therapy (CBT). The CBM-I training is offered as the first step in treatment, followed by CBT. CBM-I is compared with a waitlist condition also followed by CBT. Advantages of CBM-I compared with existing interventions are: the CBM-I training is relatively short (4 weeks), it can start during a natural waitlist that usually exists (before a therapist is available), CBM-I is motivating for the patient, can be completed at home, is cheap and easy to implement. The first research question is: Does CBM-I result in a decrease of obsessive-compulsive complaints compared to the waitlist condition? The second research question is: Is there a favourable effect of the CBM-I training (compared to the waitlist condition) on subsequent CBT? If CBM-I leads to a significant improvement in OCD severity and/or if CBM positively affects the effect of CBT, than adding a pre-treatment CBM-I training to CBT may result in more effective treatment for children with OCD, an early start of treatment (no/shorter waitlist period), and a reduction of the costs of treatment.
- Main changes (audit trail)
- RECORD22-nov-2013 - 19-aug-2017


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