search  
 


Home

Who are we?

Why
register?


Signup for
registration


Online registration

Log in to register
your trial


Search a trial

NRT en CCMO

Contact

NEDERLANDS





MetaRegister
van CCT (UK)


ISRCTN-Register
van CCT (UK)


What is the clinical relevance of exercise induced increases in cardiac troponin levels on survival and cardiovascular incidents?


- candidate number15761
- NTR NumberNTR4295
- ISRCTNISRCTN wordt niet meer aangevraagd.
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR26-nov-2013
- Secondary IDsTE/CMO/2013/402 De klinische relevantie van inspanningsgeïnduceerde troponine stijging
- Public TitleWhat is the clinical relevance of exercise induced increases in cardiac troponin levels on survival and cardiovascular incidents?
- Scientific TitleThe clinical relevance of exercise induced increases in cardiac troponin levels.
- ACRONYMN/A
- hypothesisBaseline resting levels of cardiac troponin have been shown to be a predictor fur future cardiovascular events and mortality. We hypothesize that the exercise induced increases in cardiac troponins may be a superior predictor for survival and CVD events.
- Healt Condition(s) or Problem(s) studiedExcercise capacity, Biomarkers, Troponin, Athletes, Walking
- Inclusion criteriaAge > 18 years
Participant of the Nijmegen Four Days Marches
- Exclusion criteriaThere are no specific exclusion criteria.
- mec approval receivedyes
- multicenter trialno
- randomisedno
- groupParallel
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-jan-2008
- planned closingdate31-dec-2017
- Target number of participants500
- InterventionsTo study the 5-year predictive power of exercise-induced cTn elevations, I will adopt a semi-prospective follow-up design. Data regarding the incidence of cardiovascular diseases, cardiovascular incidents and mortality (all-cause and CVD specific) will be collected annually. Subjects that successfully completed the first day of the Nijmegen Four Days Marches will be eligible for inclusion. Blood samples are collected pre and post exercise and high sensitivity cardiac troponin I levels are determined accordingly. The incidence of cardiovascular events is scored with the ICD-10 I00-99 classifications using a validated internet based questionnaire (SNAP software). Furthermore, national registers will be used to determine survival/mortality status of participants.
- Primary outcomeThe survival / mortality status of subjects is checked annually, using national registers.
- Secondary outcomeThe annual incidence of cardiovascular events is scored with the ICD-10 I00-99 classifications using a validated internet based questionnaire (SNAP software).
- TimepointsThere will be an annual follow-up regarding the health status of each subject.
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES Maria Hopman
- CONTACT for SCIENTIFIC QUERIES Maria Hopman
- Sponsor/Initiator Radboud University Medical Center Nijmegen
- Funding
(Source(s) of Monetary or Material Support)
Radboud University Medical Centre Nijmegen
- PublicationsN/A
- Brief summaryExercise-induced cardiac troponin elevations are frequently observed in athletes. The clinical relevance of this phenomenon is currently unknown. This study aims to determine the predictive capacity of exercise-induced cTn elevations for future cardiovascular events and mortality. Therefore we will include 500 participants in this trial and adopt a 5-year follow-up design. Data regarding the incidence of cardiovascular diseases, cardiovascular incidents and mortality (all-cause and CVD specific) will be collected annually.
- Main changes (audit trail)
- RECORD26-nov-2013 - 3-jan-2014


  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar nederlands@trialregister.nl